Open Access System for Information Sharing

Login Library

 

Article
Cited 10 time in webofscience Cited 11 time in scopus
Metadata Downloads
Full metadata record
Files in This Item:
There are no files associated with this item.
DC FieldValueLanguage
dc.contributor.authorSung, Wonmo-
dc.contributor.authorJeong, Yoon-
dc.contributor.authorKim, Hyejin-
dc.contributor.authorJeong, Hoibin-
dc.contributor.authorGrassberger, Clemens-
dc.contributor.authorJung, Seongmoon-
dc.contributor.authorAhn, G-One-
dc.contributor.authorKim, Il Han-
dc.contributor.authorSchuemann, Jan-
dc.contributor.authorLee, Kangwon-
dc.contributor.authorYe, Sung-Joon-
dc.date.accessioned2019-07-03T09:30:04Z-
dc.date.available2019-07-03T09:30:04Z-
dc.date.created2018-12-28-
dc.date.issued2018-11-
dc.identifier.issn0033-7587-
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/99230-
dc.description.abstractRadioenhancement of gold nanoparticles (GNPs) has shown great potential for increasing the therapeutic efficiency of radiotherapy. Here we report on a computational model of radiation response, which was developed to predict the survival curves of breast cancer cells incubated with GNPs. The amount of GNP uptake was estimated using inductively coupled plasma-mass spectroscopy, and the three-dimensional (3D) intracellular distribution of GNPs was obtained using optical diffraction tomography. The developed computational model utilized the 3D live cell imaging and recent Monte Carlo techniques to calculate microscopic dose distributions within the cell. Clonogenic assays with and without GNPs were performed to estimate the radioenhancement for 150 kVp X rays in terms of cell survival fractions. Measured cell survival fractions were comparable with the computational model. (C) 2018 by Radiation Research Society-
dc.languageEnglish-
dc.publisherRadiation Research Society-
dc.relation.isPartOfRadiation Research-
dc.titleComputational Modeling and Clonogenic Assay for Radioenhancement o Gold Nanoparticles Using 3D Live Cell Images-
dc.typeArticle-
dc.identifier.doi10.1667/RR15134.1-
dc.type.rimsART-
dc.identifier.bibliographicCitationRadiation Research, v.190, no.5, pp.558 - 564-
dc.identifier.wosid000452084900010-
dc.citation.endPage564-
dc.citation.number5-
dc.citation.startPage558-
dc.citation.titleRadiation Research-
dc.citation.volume190-
dc.contributor.affiliatedAuthorAhn, G-One-
dc.identifier.scopusid2-s2.0-85056413188-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.type.docTypeArticle-
dc.subject.keywordPlusENHANCED RADIOTHERAPY-
dc.subject.keywordPlusMEGAVOLTAGE PHOTONS-
dc.subject.keywordPlusTRACK STRUCTURE-
dc.subject.keywordPlusRADIOSENSITIZATION-
dc.subject.keywordPlusMICROSCOPY-
dc.subject.keywordPlusPROTONS-
dc.subject.keywordPlusTOPAS-
dc.relation.journalWebOfScienceCategoryBiology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.relation.journalWebOfScienceCategoryRadiology, Nuclear Medicine & Medical Imaging-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaLife Sciences & Biomedicine - Other Topics-
dc.relation.journalResearchAreaBiophysics-
dc.relation.journalResearchAreaRadiology, Nuclear Medicine & Medical Imaging-

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

안지완AHN, G ONE
Div of Integrative Biosci & Biotech
Read more

Views & Downloads

Browse