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Cited 21 time in webofscience Cited 22 time in scopus
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dc.contributor.authorAn, K-
dc.contributor.authorJung, JH-
dc.contributor.authorJeong, AY-
dc.contributor.authorKim, HG-
dc.contributor.authorJung, SY-
dc.contributor.authorLee, K-
dc.contributor.authorKim, HJ-
dc.contributor.authorKim, SJ-
dc.contributor.authorJeong, TY-
dc.contributor.authorSon, Y-
dc.contributor.authorKim, HS-
dc.contributor.authorKim, JH-
dc.date.accessioned2015-06-25T01:35:33Z-
dc.date.available2015-06-25T01:35:33Z-
dc.date.created2014-11-26-
dc.date.issued2014-11-
dc.identifier.issn2041-4889-
dc.identifier.other2015-OAK-0000030471en_US
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/9867-
dc.description.abstractReductions in hippocampal neurite complexity and synaptic plasticity are believed to contribute to the progressive impairment in episodic memory and the mild cognitive decline that occur particularly in the early stages of Alzheimer's disease (AD). Despite the functional and therapeutic importance for patients with AD, intervention to rescue or normalize dendritic elaboration and synaptic plasticity is scarcely provided. Here we show that overexpression of neuritin, an activity-dependent protein, promoted neurite outgrowth and maturation of synapses in parallel with enhanced basal synaptic transmission in cultured hippocampal neurons. Importantly, exogenous application of recombinant neuritin fully restored dendritic complexity as well as spine density in hippocampal neurons prepared from Tg2576 mice, whereas it did not affect neurite branching of neurons from their wild-type littermates. We also showed that soluble recombinant neuritin, when chronically infused into the brains of Tg2576 mice, normalized synaptic plasticity in acute hippocampal slices, leading to intact long-term potentiation. By revealing the protective actions of soluble neuritin against AD-related neural defects, we provide a potential therapeutic approach for patients with AD.-
dc.description.statementofresponsibilityopenen_US
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfCell death and disease-
dc.rightsBY_NC_NDen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/kren_US
dc.subjectTERM SYNAPTIC PLASTICITY-
dc.subjectAMYLOID-BETA PROTEIN-
dc.subjectDENDRITIC SPINES-
dc.subjectMOUSE MODEL-
dc.subjectA-BETA-
dc.subjectVISUAL-CORTEX-
dc.subjectIN-VIVO-
dc.subjectANTIDEPRESSANT ACTIONS-
dc.subjectCASPASE-3 ACTIVATION-
dc.subjectPYRAMIDAL NEURONS-
dc.titleNeuritin can normalize neural deficits of Alzheimer's disease-
dc.typeArticle-
dc.contributor.college생명과학과en_US
dc.identifier.doi10.1038/CDDIS.2014.478-
dc.author.googleK Anen_US
dc.author.googleJ H Jungen_US
dc.author.googleJ-H Kimen_US
dc.author.googleH-S Kimen_US
dc.author.googleY Sonen_US
dc.author.googleT-Y Jeongen_US
dc.author.googleS-J Kimen_US
dc.author.googleH J Kimen_US
dc.author.googleK Leeen_US
dc.author.googleS Y Jungen_US
dc.author.googleH G Kimen_US
dc.author.googleA Y Jeongen_US
dc.relation.volume5en_US
dc.relation.startpageE1523en_US
dc.contributor.id10114767en_US
dc.relation.journalCell death and diseaseen_US
dc.relation.indexSCI급, SCOPUS 등재논문en_US
dc.relation.sciSCIen_US
dc.collections.nameJournal Papersen_US
dc.type.rimsART-
dc.identifier.bibliographicCitationCell death and disease, v.5, pp.E1523-
dc.identifier.wosid000345643900017-
dc.date.tcdate2019-01-01-
dc.citation.startPageE1523-
dc.citation.titleCell death and disease-
dc.citation.volume5-
dc.contributor.affiliatedAuthorKim, JH-
dc.identifier.scopusid2-s2.0-84927948445-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.wostc11-
dc.description.scptc12*
dc.date.scptcdate2018-10-274*
dc.type.docTypeArticle-
dc.subject.keywordPlusTERM SYNAPTIC PLASTICITY-
dc.subject.keywordPlusAMYLOID-BETA PROTEIN-
dc.subject.keywordPlusDENDRITIC SPINES-
dc.subject.keywordPlusMOUSE MODEL-
dc.subject.keywordPlusA-BETA-
dc.subject.keywordPlusVISUAL-CORTEX-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusANTIDEPRESSANT ACTIONS-
dc.subject.keywordPlusCASPASE-3 ACTIVATION-
dc.subject.keywordPlusPYRAMIDAL NEURONS-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaCell Biology-

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김정훈KIM, JOUNG HUN
Dept of Life Sciences
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