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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines SCIE SCOPUS

Title
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Authors
Thery, ClotildeWitwer, Kenneth W.Gho, Yong SongAikawa, ElenaJose Alcaraz, MariaAnderson, Johnathon D.Andriantsitohaina, RamarosonAntoniou, AnnaArab, TaninaArcher, FabienneAtkin-Smith, Georgia K.Ayre, D. CraigBach, Jean-MarieBachurski, DanielBaharvand, HosseinBalaj, LeonoraBaldacchino, ShawnBauer, Natalie N.Baxter, Amy A.Bebawy, MaryBeckham, CarlaZavec, Apolonija BedinaBenmoussa, AbderrahimBerardi, Anna C.Bergese, PaoloBielska, EwaBlenkiron, CherieBobis-Wozowicz, SylwiaBoilard, EricBoireau, WilfridBongiovanni, AntonellaBorras, Francesc E.Bosch, SteffiBoulanger, Chantal M.Breakefield, XandraBreglio, Andrew M.Brennan, Meadhbh A.Brigstock, David R.Brisson, AlainBroekman, Marike L. D.Bromberg, Jacqueline F.Bryl-Gorecka, PaulinaBuch, ShilpaBuck, Amy H.Burger, DylanBusatto, SaraBuschmann, DominikBussolati, BenedettaBuzas, Edit, IByrd, James BryanCamussi, GiovanniCarter, David R. F.Caruso, SarahChamley, Lawrence W.Chang, Yu-TingChaudhuri, Amrita DattaChen, ChihchenChen, ShuaiCheng, LesleyChin, Andrew R.Clayton, AledClerici, Stefano P.Cocks, AlexCocucci, EmanueleCoffey, Robert J.Cordeiro-da-Silva, AnabelaCouch, YvonneCoumans, Frank A. W.Coyle, BethCrescitelli, RossellaCriado, Miria FerreiraD'Souza-Schorey, CrislynDas, Saumyade Candia, PaolaDe Santana Junior, Eliezer F.De Wever, Olivierdel Portillo, Hernando A.Demaret, TanguyDeville, SarahDevitt, AndrewDhondt, BertDi Vizio, DoloresDieterich, Lothar C.Dolo, VincenzaDominguez Rubio, Ana PaulaDominici, MassimoDourado, Mauricio R.Driedonks, Tom A. P.Duarte, Filipe, VDuncan, Heather M.Eichenberger, Ramon M.Ekstrom, KarinAndaloussi, Samir E. L.Elie-Caille, CelineErdbrugger, UtaFalcon-Perez, Juan M.Fatima, FarahFish, Jason E.Flores-Bellver, MiguelForsonits, AndrasFrelet-Barrand, AnnieFricke, FabiaFuhrmann, GregorGabrielsson, SusanneGamez-Valero, AnaGardiner, ChrisGaertner, KathrinGaudin, RaphaelGiebel, BerndGilbert, CarolineGimona, MarioGiusti, IlariaGoberdhan, Deborah C., IGoergens, AndreGorski, Sharon M.Greening, David W.Gross, Julia ChristinaGualerzi, AliceGupta, Gopal N.Gustafson, DakotaHandberg, AaseHaraszti, Reka A.Harrison, PaulHegyesi, HargitaHendrix, AnHill, Andrew F.Hochberg, Fred H.Hoffmann, Karl F.Holder, BethHolthofer, HarryHosseinkhani, BaharakHu, GuokuHuang, YiyaoHuber, VeronicaHunt, StuartIbrahim, Ahmed Gamal-EldinIkezu, TsuneyaInal, Jameel M.Isin, MustafaIvanova, AlenaJackson, Hannah K.Jacobsen, SorenJay, Steven M.Jayachandran, MuthuvelJenster, GuidoJiang, LanzhouJohnson, Suzanne M.Jones, Jennifer C.Jong, AmbroseJovanovic-Talisman, TijanaJung, StephanieKalluri, RaghuKano, Shin-ichiKaur, SukhbirKawamura, YumiKeller, Evan T.Khamari, DelaramKhomyakova, ElenaKhvorova, AnastasiaKierulf, PeterKim, Kwang PyoKislinger, ThomasKlingeborn, MikaelKlinke, David J., IIKornek, MiroslawKosanovic, Maja M.Kovacs, Arpad FerencKraemer-Albers, Eva-MariaKrasemann, SusanneKrause, MirjaKurochkin, Igor, VKusuma, Gina D.Kuypers, SorenLaitinen, SaaraLangevin, Scott M.Languino, Lucia R.Lannigan, JoanneLasser, CeciliaLaurent, Louise C.Lavieu, GregoryLazaro-Ibanez, ElisaLe Lay, SoazigLee, Myung-ShinLee, Yi Xin FionaLemos, Debora S.Lenassi, MetkaLeszczynska, AleksandraLi, Isaac T. S.Liao, KeLibregts, Sten F.Ligeti, ErzsebetLim, RebeccaLim, Sai KiangLine, AijaLinnemannstoens, KarenLlorente, AliciaLombard, Catherine A.Lorenowicz, Magdalena J.Lorincz, Akos M.Lotvall, JanLovett, JasonLowry, Michelle C.Loyer, XavierLu, QuanLukomska, BarbaraLunavat, Taral R.Maas, Sybren L. N.Malhi, HarmeetMarcilla, AntonioMariani, JacopoMariscal, JavierMartens-Uzunova, Elena S.Martin-Jaular, LorenaMartinez, M. CarmenMartins, Vilma ReginaMathieu, MathildeMathivanan, SureshMaugeri, MarcoMcGinnis, Lynda K.McVey, Mark J.Meckes, David G., Jr.Meehan, Katie L.Mertens, IngeMinciacchi, Valentina R.Moller, AndreasJorgensen, Malene MollerMorales-Kastresana, AizeaMorhayim, JessMullier, FrancoisMuraca, MaurizioMusante, LucaMussack, VeronikaMuth, Dillon C.Myburgh, Kathryn H.Najrana, TanbirNawaz, MuhammadNazarenko, IrinaNejsum, PeterNeri, ChristianNeri, TommasoNieuwland, RienkNimrichter, LeonardoNolan, John P.Hoen, Esther N. M. Nolte-'tHooten, Nicole NorenO'Driscoll, LorraineO'Grady, TinaO'Loghlen, AnaOchiya, TakahiroOlivier, MartinOrtiz, AlbertoOrtiz, Luis A.Osteikoetxea, XabierOstegaard, OleOstrowski, MatiasPark, JaesungPegtel, D. MichielPeinado, HectorPerut, FrancescaPfaffl, Michael W.Phinney, Donald G.Pieters, Bartijn C. H.Pink, Ryan C.Pisetsky, David S.von Strandmann, Elke PoggePolakovicova, IvaPoon, Ivan K. H.Powell, Bonita H.Prada, IlariaPulliam, LynnQuesenberry, PeterRadeghieri, AnnalisaRaffai, Robert L.Raimondo, StefaniaRak, JanuszRamirez, Marcel, IRaposo, GracaRayyan, Morsi S.Regev-Rudzki, NetaRicklefs, Franz L.Robbins, Paul D.Roberts, David D.Rodrigues, Silvia C.Rohde, EvaRome, SophieRouschop, Kasper M. A.Rughetti, AureliaRussell, Ashley E.Saa, PaulaSahoo, SusmitaSalas-Huenuleo, EdisonSanchez, CatherineSaugstad, Julie A.Saul, Meike J.Schiffelers, Raymond M.Schneider, RaphaelSchoyen, Tine HiorthScott, AaronShahaj, EriominaSharma, ShivaniShatnyeva, OlgaShekari, FaezehShelke, Ganesh VilasShetty, Ashok K.Shiba, KiyotakaSiljander, Pia R-MSilva, Andreia M.Skowronek, AgataSnyder, Orman L., IISoares, Rodrigo PedroSodar, Barbara W.Soekmadji, CarolinaSotillo, JavierStahl, Philip D.Stoorvogel, WillemStott, Shannon L.Strasser, Erwin F.Swift, SimonTahara, HidetoshiTewari, MuneeshTimms, KateTiwari, SwastiTixeira, RochelleTkach, MercedesToh, Wei SeongTomasini, RichardTorrecilhas, Ana ClaudiaPablo Tosar, JuanToxavidis, VasilisUrbanelli, LorenaVader, Pietervan Balkom, Bas W. M.van der Grein, Susanne G.Van Deun, Janvan Herwijnen, Martijn J. C.Van Keuren-Jensen, Kendallvan Niel, Guillaumevan Royen, Martin E.van Wijnen, Andre J.Helena Vasconcelos, M.Vechetti, Ivan J., Jr.Veit, Tiago D.Vella, Laura J.Velot, EmilieVerweij, Frederik J.Vestad, BeateVinas, Jose L.Visnovitz, TamasVukman, Krisztina V.Wahlgren, JessicaWatson, Dionysios C.Wauben, Marca H. M.Weaver, AlissaWebber, Jason P.Weber, ViktoriaWehman, Ann M.Weiss, Daniel J.Welsh, Joshua A.Wendt, SebastianWheelock, Asa M.Wiener, ZoltanWitte, LeonieWolfram, JoyXagorari, AngelikiXander, PatriciaXu, JingYan, XiaomeiYanez-Mo, MariaYin, HangYuana, YuanaZappulli, ValentinaZarubova, JanaZekas, VytautasZhang, Jian-yeZhao, ZezhouZheng, LeiZheutlin, Alexander R.Zickler, Antje M.Zimmermann, PascaleZivkovic, Angela M.Zocco, DavideZuba-Surma, Ewa K.
Date Issued
2018-11
Publisher
Co-Action Publishing
Abstract
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
URI
https://oasis.postech.ac.kr/handle/2014.oak/98580
DOI
10.1080/20013078.2018.1535750
ISSN
2001-3078
Article Type
Article
Citation
Journal of Extracellular Vesicles, vol. 8, no. 1, 2018-11
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박재성PARK, JAE SUNG
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