Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T cells
SCIE
SCOPUS
- Title
- Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T cells
- Authors
- Verma, Ravi; LEE, CHANGHON; Jeun, Eun-Ji; JAEU, YI; Kim, Kwang Soon; Ghosh, Ambarnil; BYUN, SEOHYUN; Lee, Choong-Gu; Kang, Hye-Ji; Kim, Gi-Cheon; Jun, Chang-Duk; Jan, Gwenael; Suh, Chang-Hee; Jung, Ju-Yang; Sprent, Jonathan; Rudra, Dipayan; De Castro, Cristina; Molinaro, Antonio; SURH, CHARLES D; IM, SIN HYEOG
- Date Issued
- 2018-10
- Publisher
- AAAS
- Abstract
- Dysregulation of intestinal microflora is linked to inflammatory disorders associated with compromised immunosuppressive functions of Foxp3+ T regulatory (Treg) cells. Although mucosa-associated commensal microbiota has been implicated in Treg generation, molecular identities of the "effector" components controlling this process remain largely unknown. Here, we have defined Bifidobacterium bifidum as a potent inducer of Foxp3+ Treg cells with diverse T cell receptor specificity to dietary antigens, commensal bacteria, and B. bifidum itself. Cell surface β-glucan/galactan (CSGG) polysaccharides of B. bifidum were identified as key components responsible for Treg induction. CSGG efficiently recapitulated the activity of whole bacteria and acted via regulatory dendritic cells through a partially Toll-like receptor 2-mediated mechanism. Treg cells induced by B. bifidum or purified CSGG display stable and robust suppressive capacity toward experimental colitis. By identifying CSGG as a functional component of Treg-inducing bacteria, our studies highlight the immunomodulatory potential of CSGG and CSGG-producing microbes.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/94274
- DOI
- 10.1126/sciimmunol.aat6975
- ISSN
- 2470-9468
- Article Type
- Article
- Citation
- Science immunology, vol. 3, no. 28, page. 6975, 2018-10
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