Flexible Tetrahydropyran Synthesis from Homopropargylic Alcohols Using Sequential Pd-Au Catalysis
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- Title
- Flexible Tetrahydropyran Synthesis from Homopropargylic Alcohols Using Sequential Pd-Au Catalysis
- Authors
- Kim, Jungjoon; Jeong, Wook; Rhee, Young Ho
- Date Issued
- 2017-01
- Publisher
- AMER CHEMICAL SOC
- Abstract
- A flexible synthetic method toward highly :substituted tetrahydropyran is reported: The key transformation involves atom-efficient sequential metal catalysis, consisting of Pd-catalyzed addition of homopropargylic alcohols to alkoxyallene and the subsequent gold(I)-catalyzed cycloisomerization. Notably, this method gives access to, both 2,6-cis- and 2,6-trans-tetrahydropyrans possessing diverse substitution patterns.
- Keywords
- RING-CLOSING METATHESIS; INTERMOLECULAR HYDROALKOXYLATION; RAUTENSTRAUCH REARRANGEMENT; STEREOSELECTIVE-SYNTHESIS; ENANTIOSELECTIVE ACCESS; ASYMMETRIC-SYNTHESIS; NATURAL-PRODUCTS; GOLD; ALLENES; ETHERS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50618
- DOI
- 10.1021/acs.orglett.6b03532
- ISSN
- 1523-7060
- Article Type
- Article
- Citation
- ORGANIC LETTERS, vol. 19, no. 1, page. 242 - 245, 2017-01
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