Mechanical properties and degradation behaviors of hyaluronic acid hydrogels cross-linked at various cross-linking densities
SCIE
SCOPUS
- Title
- Mechanical properties and degradation behaviors of hyaluronic acid hydrogels cross-linked at various cross-linking densities
- Authors
- Jeon, O; Song, SJ; Lee, KJ; Park, MH; Lee, SH; Hahn, SK; Kim, S; Kim, BS
- Date Issued
- 2007-10-01
- Publisher
- ELSEVIER SCI LTD
- Abstract
- The effect of cross-linking density of hyaluronic acid (HA) hydrogels on mechanical properties and degradation behaviors has been investigated. HA hydrogels were prepared by the covalent cross-linking of HA with poly(ethylene glycol)-diamine with two different molecular weights at various cross-linking densities. The elastic modulus increased gradually as the theoretical cross-linking density of HA hydrogels increased from 0% to 20%. However, as the theoretical cross-linking density increased above 20%, the elastic modulus decreased. At a theoretical cross-linking density of 20%, the elastic modulus increased as the molecular weight of the cross-linking molecule decreased. In vitro degradation rates of HA hydrogels decreased as the molecular weight of the cross-linking molecule decreased at a theoretical cross-linking density of 20%. The degradation rate of the cross-linked HA hydrogels decreased with increases in the theoretical cross-linking density from 0% to 20%. However, there was no significant difference in the degradation rate as the theoretical cross-linking density increased above 30%. With controllable mechanical properties and degradation rates, the developed HA hydrogels would be further investigated for various medical applications. (c) 2007 Elsevier Ltd. All rights reserved.
- Keywords
- cross-linking; degradation; elastic modulus; hyaluronic acid; hydrogel; poly(ethylene glycol); FIBROBLAST-GROWTH-FACTOR; FUNCTIONALIZED DERIVATIVES; FIBRIN MATRIX; TRANSPLANTATION; BIOMATERIALS; RIGIDITY; ALGINATE; RELEASE; FILMS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/29483
- DOI
- 10.1016/j.carbpol.2007.04.002
- ISSN
- 0144-8617
- Article Type
- Article
- Citation
- CARBOHYDRATE POLYMERS, vol. 70, no. 3, page. 251 - 257, 2007-10-01
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