Open Access System for Information Sharing

Login Library

 

Article
Cited 70 time in webofscience Cited 71 time in scopus
Metadata Downloads
Full metadata record
Files in This Item:
There are no files associated with this item.
DC FieldValueLanguage
dc.contributor.authorYoon, CMko
dc.contributor.authorHong, BSko
dc.contributor.authorMoon, HGko
dc.contributor.authorLim, Sko
dc.contributor.authorSuh, PGko
dc.contributor.authorKim, YKko
dc.contributor.authorChae, CBko
dc.contributor.authorGho, YSko
dc.date.available2016-04-01T09:05:02Z-
dc.date.created2009-03-05-
dc.date.issued2008-01-
dc.identifier.citationBLOOD, v.112, no.4, pp.1129 - 1138-
dc.identifier.issn0006-4971-
dc.identifier.other2008-OAK-0000010900-
dc.identifier.urihttp://oasis.postech.ac.kr/handle/2014.oak/29420-
dc.description.abstractThe lymphatic system plays pivotal roles in mediating tissue fluid homeostasis and immunity, and excessive lymphatic vessel formation is implicated in many pathological conditions, which include inflammation and tumor metastasis. However, the molecular mechanisms that regulate lymphatic vessel formation remain poorly characterized. Sphingosine-1-phosphate (S1P) is a potent bioactive lipid that is implicated in a variety of biologic processes such as inflammatory responses and angiogenesis. Here, we first report that SIP acts as a lymphangiogenic mediator. S1P induced migration, capillary-like tube formation, and intracellular Ca2+ mobilization, but not proliferation, in human lymphatic endothelial cells (HLECs) in vitro. Moreover, a Matrigel plug assay demonstrated that SIP promoted the outgrowth of new lymphatic vessels in vivo. HLECs expressed S1P1 and S1P3, and both RNA interference-mediated down-regulation of S1P1 and an S1P1 antagonist significantly blocked SIP-mediated lymphangiogenesis. Furthermore, pertussis toxin, U73122, and BAPTA-AM efficiently blocked S1P-induced in vitro lymphangiogenesis and intracellular Ca2+ mobilization of HLECs, indicating that S1P promotes lymphangiogenesis by stimulating S1P1/G(i)/phospholipase C/Ca2+ signaling pathways. Our results suggest that SIP is the first lymphangiogenic bioactive lipid to be identified, and that S1P and its receptors might serve as new therapeutic targets against inflammatory diseases and lymphatic metastasis in tumors.-
dc.description.statementofresponsibilityX-
dc.languageEnglish-
dc.publisherAMER SOC HEMATOLOGY-
dc.subjectENDOTHELIAL-CELL MIGRATION-
dc.subjectLYMPHATIC VESSEL FORMATION-
dc.subjectPROTEIN-COUPLED RECEPTORS-
dc.subjectGROWTH-FACTOR-
dc.subjectVEGF-C-
dc.subjectLYSOPHOSPHATIDIC ACID-
dc.subjectEXTRACELLULAR EXPORT-
dc.subjectVASCULAR MATURATION-
dc.subjectADHESION MOLECULE-1-
dc.subjectNITRIC-OXIDE-
dc.titleSphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/G(i)/PLC/Ca2+ signaling pathways-
dc.typeArticle-
dc.contributor.college생명과학과-
dc.identifier.doi10.1182/BLOOD-2007-11-125203-
dc.author.googleYoon, CM-
dc.author.googleHong, BS-
dc.author.googleMoon, HG-
dc.author.googleLim, S-
dc.author.googleSuh, PG-
dc.author.googleKim, YK-
dc.author.googleChae, CB-
dc.author.googleGho, YS-
dc.relation.volume112-
dc.relation.issue4-
dc.relation.startpage1129-
dc.relation.lastpage1138-
dc.contributor.id10138843-
dc.publisher.locationUS-
dc.relation.journalBLOOD-
dc.relation.indexSCI급, SCOPUS 등재논문-
dc.collections.nameJournal Papers-
dc.type.rimsART-
dc.contributor.localauthorKim, YK-
dc.contributor.localauthorGho, YS-
dc.contributor.nonIdAuthorYoon, CM-
dc.contributor.nonIdAuthorHong, BS-
dc.contributor.nonIdAuthorMoon, HG-
dc.contributor.nonIdAuthorLim, S-
dc.contributor.nonIdAuthorSuh, PG-
dc.contributor.nonIdAuthorChae, CB-
dc.identifier.wosid000258392300035-
dc.date.tcdate2019-02-01-
dc.citation.endPage1138-
dc.citation.number4-
dc.citation.startPage1129-
dc.citation.titleBLOOD-
dc.citation.volume112-
dc.identifier.scopusid2-s2.0-51649099579-
dc.description.journalClass1-
dc.description.wostc60-
dc.description.scptc57*
dc.date.scptcdate2018-05-121*

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

고용송GHO, YONG SONG
Dept of Life Sciences
Read more

Views & Downloads

Browse