Synthesis of 5-isoxazol-5-yl-2 '-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses
SCIE
SCOPUS
- Title
- Synthesis of 5-isoxazol-5-yl-2 '-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses
- Authors
- Lee, YS; Park, SM; Kim, BH
- Date Issued
- 2009-02-15
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- This paper describes a simple method for synthesizing a small library of 5-isoxazol-5-yl-2 '-deoxyuridines from 5-iodo-2 '-deoxyuridine. Nitrile oxides were generated in situ from oximes using a commercial bleaching agent; their cycloaddition with 5-ethynyl-2 '-deoxyuridine yielded isoxazoles possessing activity against herpes simplex viruses 1 and 2, Encephalomyocarditis virus, Coxsackie B3, and vesicular stomatitis virus; these isoxazoles were, however, inactive against corona virus, influenza virus, and HIV. (C) 2009 Published by Elsevier Ltd.
- Keywords
- HSV; Antiviral; EMCV; Cox. B3; VSV; Isoxazole; Isoxazole nucleosides; Antiviral nucleoside; [3+2] Cycloaddition; HERPES-SIMPLEX-VIRUS; THYMIDINE KINASE; ANALOGS; ISOXAZOLE; TYPE-1; CHEMOTHERAPY; AFFINITY; DESIGN
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/29115
- DOI
- 10.1016/j.bmcl.2008.12.103
- ISSN
- 0960-894X
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 4, page. 1126 - 1128, 2009-02-15
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- There are no files associated with this item.
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