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Development of a hybrid scaffold and a bioreactor for cartilage regeneration

Title
Development of a hybrid scaffold and a bioreactor for cartilage regeneration
Authors
Seung-Jae LeeIn Hwan LeeJeong Hun ParkSo-Jung GwakJong-Won RhieCho, DWTae Jo KoKim, DS
POSTECH Authors
Cho, DWKim, DS
Date Issued
Oct-2009
Publisher
SCIENCE PRESS
Abstract
We developed a hybrid scaffold and a bioreactor for cartilage regeneration. The hybrid scaffold was developed as combination of two components: a biodegradable framework and hydrogel-containing chondrocytes. We performed the MTT cell proliferation assay to compare the proliferation and viability of chondrocytes on three types of scaffolds: an alginate gel, the hybrid scaffold, and an alginate sponge. Cells were encapsulated in 2% agarose gel. The bioreactor consisted of a circulation system and a compression system. We performed dynamic cell culture on these agarose gels in the bioreactor for 3 days.
Keywords
cartilage; scaffold; bioreactor; alginate; agarose; CARBONATE-BASED PREPOLYMERS
URI
http://oasis.postech.ac.kr/handle/2014.oak/27832
DOI
10.1007/S11434-009-0
ISSN
1001-6538
Article Type
Article
Citation
CHINESE SCIENCE BULLETIN, vol. 54, no. 19, page. 3608 - 3612, 2009-10
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조동우CHO, DONG WOO
Dept of Mechanical Enginrg
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