Open Access System for Information Sharing

Login Library

 

Article
Cited 23 time in webofscience Cited 24 time in scopus
Metadata Downloads
Full metadata record
Files in This Item:
There are no files associated with this item.
DC FieldValueLanguage
dc.contributor.authorNam, HJ-
dc.contributor.authorSong, MY-
dc.contributor.authorChoi, DH-
dc.contributor.authorYang, SH-
dc.contributor.authorJin, HT-
dc.contributor.authorSung, YC-
dc.date.accessioned2016-04-01T02:46:24Z-
dc.date.available2016-04-01T02:46:24Z-
dc.date.created2010-09-27-
dc.date.issued2010-02-
dc.identifier.issn0014-2980-
dc.identifier.other2010-OAK-0000021683-
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/25738-
dc.description.abstractIL-7 plays a crucial role in the homeostatic proliferation, differentiation and survival of T cells, as well as in the survival and proliferation of precursor B cells. Here, we demonstrated that utilizing nonlytic Fc-fused IL-7 (IL-7-Fc(m)) as a genetic adjuvant significantly enhanced not only CD4(+) but also CD8(+) T-cell responses by E7 DNA immunization, in addition to improving protection against TC-1-induced tumors in comparison to IL-7 alone. Similar results were obtained in OT-1 adoptive transfer experiments with OVA DNA injection, suggesting independence from antigenic nature and experimental conditions. In particular, the increased frequency of CD8(+) T cells was mainly due to enhanced T-cell proliferation in T-cell priming, and not to decreased cellular apoptosis. Interestingly, the enhanced adjuvant effect was not seen in the co-delivery of lytic Fc-fused IL-7 (IL-7-Fc) which increases T-cell apoptosis as well as T-cell proliferation, suggesting that the T-cell proliferative effect may be neutralized by T-cell apoptosis. Thus, our findings suggest that nonlytic Fc, in contrast to lytic Fc, fusion to cytokines may provide an insight in designing a potent genetic adjuvant for inducing CD4(+) and CD8(+) T-cell responses.-
dc.description.statementofresponsibilityX-
dc.languageEnglish-
dc.publisherWILEY-VCH-
dc.relation.isPartOfEUROPEAN JOURNAL OF IMMUNOLOGY-
dc.subjectIL-7-
dc.subjectLytic and nonlytic Fc fusion-
dc.subjectT-cell responses-
dc.subjectVaccination-
dc.subjectIN-VIVO-
dc.subjectIMMUNE-RESPONSES-
dc.subjectIL-15-
dc.subjectINTERLEUKIN-7-
dc.subjectHOMEOSTASIS-
dc.subjectANTIBODIES-
dc.subjectRECEPTORS-
dc.subjectMICE-
dc.subjectIMMUNOTHERAPY-
dc.subjectCOMPLEXES-
dc.titleMarked enhancement of antigen-specific T cell responses by IL-7-fused nonlytic, but not lytic, Fc as a genetic adjuvant.-
dc.typeArticle-
dc.contributor.college융합생명공학부-
dc.identifier.doi10.1002/EJI.200939271-
dc.author.googleNam, HJ-
dc.author.googleSong, MY-
dc.author.googleChoi, DH-
dc.author.googleYang, SH-
dc.author.googleJin, HT-
dc.author.googleSung, YC-
dc.relation.volume40-
dc.relation.issue2-
dc.relation.startpage351-
dc.relation.lastpage358-
dc.contributor.id10053752-
dc.relation.journalEUROPEAN JOURNAL OF IMMUNOLOGY-
dc.relation.indexSCI급, SCOPUS 등재논문-
dc.relation.sciSCI-
dc.collections.nameJournal Papers-
dc.type.rimsART-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF IMMUNOLOGY, v.40, no.2, pp.351 - 358-
dc.identifier.wosid000274670300009-
dc.date.tcdate2019-02-01-
dc.citation.endPage358-
dc.citation.number2-
dc.citation.startPage351-
dc.citation.titleEUROPEAN JOURNAL OF IMMUNOLOGY-
dc.citation.volume40-
dc.contributor.affiliatedAuthorSung, YC-
dc.identifier.scopusid2-s2.0-75149194434-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.wostc14-
dc.description.scptc15*
dc.date.scptcdate2018-05-121*
dc.type.docTypeArticle-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusIMMUNE-RESPONSES-
dc.subject.keywordPlusIL-15-
dc.subject.keywordPlusINTERLEUKIN-7-
dc.subject.keywordPlusHOMEOSTASIS-
dc.subject.keywordPlusANTIBODIES-
dc.subject.keywordPlusRECEPTORS-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusIMMUNOTHERAPY-
dc.subject.keywordPlusCOMPLEXES-
dc.subject.keywordAuthorIL-7-
dc.subject.keywordAuthorLytic and nonlytic Fc fusion-
dc.subject.keywordAuthorT-cell responses-
dc.subject.keywordAuthorVaccination-
dc.relation.journalWebOfScienceCategoryImmunology-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaImmunology-

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

성영철SUNG, YOUNG CHUL
Dept of Life Sciences
Read more

Views & Downloads

Browse