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Cited 138 time in webofscience Cited 142 time in scopus
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dc.contributor.authorLee, JS-
dc.contributor.authorKim, Y-
dc.contributor.authorKim, IS-
dc.contributor.authorKim, B-
dc.contributor.authorChoi, HJ-
dc.contributor.authorLee, JM-
dc.contributor.authorShin, HJR-
dc.contributor.authorKim, JH-
dc.contributor.authorKim, JY-
dc.contributor.authorSeo, SB-
dc.contributor.authorLee, H-
dc.contributor.authorBinda, O-
dc.contributor.authorGozani, O-
dc.contributor.authorSemenza, GL-
dc.contributor.authorKim, M-
dc.contributor.authorIl Kim, K-
dc.contributor.authorHwang, D-
dc.contributor.authorBaek, SH-
dc.date.accessioned2016-04-01T02:32:34Z-
dc.date.available2016-04-01T02:32:34Z-
dc.date.created2011-04-04-
dc.date.issued2010-07-09-
dc.identifier.issn1097-2765-
dc.identifier.other2010-OAK-0000022375-
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/25323-
dc.description.abstractLysine methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent studies have extended lysine methylation to nonhistone proteins, underlying molecular mechanisms such as the upstream signaling cascade that induces lysine methylation and downstream target genes modulated by this modification have not been elucidated. Here, we show that Reptin, a chromatin-remodeling factor, is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a. Methylated Reptin binds to the promoters of a subset of hypoxia-responsive genes and negatively regulates transcription of these genes to modulate cellular responses to hypoxia.-
dc.description.statementofresponsibilityX-
dc.languageEnglish-
dc.publisherCambridge Ma : Cell Press-
dc.relation.isPartOfMOLECULAR CELL-
dc.subjectCHROMATIN-REMODELING COMPLEX-
dc.subjectHISTONE H3 LYSINE-9-
dc.subjectMETHYLTRANSFERASE G9A-
dc.subjectCANCER-CELLS-
dc.subjectINDUCIBLE FACTOR-1-
dc.subjectMAMMALIAN-CELLS-
dc.subjectGENE-EXPRESSION-
dc.subjectBETA-
dc.subjectPROTEIN-
dc.subjectTRANSCRIPTION-
dc.titleNegative Regulation of Hypoxic Responses via Induced Reptin Methylation-
dc.typeArticle-
dc.contributor.college융합생명공학부-
dc.identifier.doi10.1016/J.MOLCEL.2010.06.008-
dc.author.googleLee, JS-
dc.author.googleKim, Y-
dc.author.googleKim, IS-
dc.author.googleKim, B-
dc.author.googleChoi, HJ-
dc.author.googleLee, JM-
dc.author.googleShin, HJR-
dc.author.googleKim, JH-
dc.author.googleKim, JY-
dc.author.googleSeo, SB-
dc.author.googleLee, H-
dc.author.googleBinda, O-
dc.author.googleGozani, O-
dc.author.googleSemenza, GL-
dc.author.googleKim, M-
dc.author.googleIl Kim, K-
dc.author.googleHwang, D-
dc.author.googleBaek, SH-
dc.relation.volume39-
dc.relation.issue1-
dc.relation.startpage71-
dc.relation.lastpage85-
dc.contributor.id10180943-
dc.relation.journalMOLECULAR CELL-
dc.relation.indexSCI급, SCOPUS 등재논문-
dc.relation.sciSCI-
dc.collections.nameJournal Papers-
dc.type.rimsART-
dc.identifier.bibliographicCitationMOLECULAR CELL, v.39, no.1, pp.71 - 85-
dc.identifier.wosid000280139200009-
dc.date.tcdate2019-02-01-
dc.citation.endPage85-
dc.citation.number1-
dc.citation.startPage71-
dc.citation.titleMOLECULAR CELL-
dc.citation.volume39-
dc.contributor.affiliatedAuthorHwang, D-
dc.identifier.scopusid2-s2.0-77954265666-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.wostc93-
dc.description.scptc88*
dc.date.scptcdate2018-05-121*
dc.type.docTypeArticle-
dc.subject.keywordPlusCHROMATIN-REMODELING COMPLEX-
dc.subject.keywordPlusHISTONE H3 LYSINE-9-
dc.subject.keywordPlusMETHYLTRANSFERASE G9A-
dc.subject.keywordPlusCANCER-CELLS-
dc.subject.keywordPlusINDUCIBLE FACTOR-1-
dc.subject.keywordPlusMAMMALIAN-CELLS-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusBETA-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusTRANSCRIPTION-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaCell Biology-

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황대희HWANG, DAEHEE
Div of Integrative Biosci & Biotech
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