Zinc(II)-Dipicolylamine-Functionalized Polydiacetylene-Liposome Microarray: A Selective and Sensitive Sensing Platform for Pyrophosphate Ions
SCIE
SCOPUS
- Title
- Zinc(II)-Dipicolylamine-Functionalized Polydiacetylene-Liposome Microarray: A Selective and Sensitive Sensing Platform for Pyrophosphate Ions
- Authors
- Kim, KM; Oh, DJ; Ahn, KH
- Date Issued
- 2011-01-03
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- A microarray-chip assay system for the fluorescence detection of phosphate-containing analytes in aqueous media has been constructed from stimuli-responsive polymerized poly(diacetylene)-liposomes for the first time. Proper combination of the liposome components (Zn-II-dipicolylamine for phosphate binding and an amine-terminated component for anchoring the liposome onto an aldehyde-derivatized glass plate), has led to a microarray chip that selectively detects pyrophosphate, an important biomarker, over competing anions, such as phosphate and adenosine triphosphate, with nanomolar sensitivity. The chip-based assay shows advantages, such as high specificity and sensitivity, over solution-based assays that use the same liposomes, and over known homogeneous molecular sensing systems.
- Keywords
- liposomes; microreactors; pyrophosphate; sensors; zinc; EXCIMER FORMATION; SENSOR; CHEMOSENSORS; WATER; SUPRAMOLECULES; RECOGNITION; VESICLES; ASSAY
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/25059
- DOI
- 10.1002/ASIA.201000621
- ISSN
- 1861-4728
- Article Type
- Article
- Citation
- CHEMISTRY-AN ASIAN JOURNAL, vol. 6, no. 1, page. 122 - 127, 2011-01-03
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- There are no files associated with this item.
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