Dynamic kinetic resolution of primary amines with a recyclable Pd nanocatalyst for racemization
SCIE
SCOPUS
- Title
- Dynamic kinetic resolution of primary amines with a recyclable Pd nanocatalyst for racemization
- Authors
- Kim, MJ; Kim, WH; Han, K; Choi, YK; Park, J
- Date Issued
- 2007-03-15
- Publisher
- AMER CHEMICAL SOC
- Abstract
- A practical procedure for the dynamic kinetic resolution (DKR) of primary amines has been developed. This procedure employs a palladium nanocatalyst as the racemization catalyst, a commercial lipase (Novozym-435) as the resolution catalyst, and ethyl acetate or ethyl methoxyacetate as the acyl donor. Eleven primary amines and one amino acid amide have been efficiently resolved with good yields (85-99%) and high enantiomeric excesses (97-99%).
- Keywords
- SECONDARY ALCOHOLS; AMBIENT-TEMPERATURE; ASYMMETRIC TRANSFORMATIONS; CATALYSTS; METAL; PALLADIUM; LIPASE; COMBINATION; EVOLUTION; ENZYMES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/23531
- DOI
- 10.1021/OL070130D
- ISSN
- 1523-7060
- Article Type
- Article
- Citation
- ORGANIC LETTERS, vol. 9, no. 6, page. 1157 - 1159, 2007-03-15
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- There are no files associated with this item.
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