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Cited 141 time in webofscience Cited 159 time in scopus
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Dynamic kinetic resolution of primary amines with a recyclable Pd nanocatalyst for racemization

Title
Dynamic kinetic resolution of primary amines with a recyclable Pd nanocatalyst for racemization
Authors
Kim, MJKim, WHHan, KChoi, YKPark, J
POSTECH Authors
Kim, MJPark, J
Date Issued
Jan-2007
Publisher
AMER CHEMICAL SOC
Abstract
A practical procedure for the dynamic kinetic resolution (DKR) of primary amines has been developed. This procedure employs a palladium nanocatalyst as the racemization catalyst, a commercial lipase (Novozym-435) as the resolution catalyst, and ethyl acetate or ethyl methoxyacetate as the acyl donor. Eleven primary amines and one amino acid amide have been efficiently resolved with good yields (85-99%) and high enantiomeric excesses (97-99%).
Keywords
SECONDARY ALCOHOLS; AMBIENT-TEMPERATURE; ASYMMETRIC TRANSFORMATIONS; CATALYSTS; METAL; PALLADIUM; LIPASE; COMBINATION; EVOLUTION; ENZYMES
URI
http://oasis.postech.ac.kr/handle/2014.oak/23531
DOI
10.1021/OL070130D
ISSN
1523-7060
Article Type
Article
Citation
ORGANIC LETTERS, vol. 9, no. 6, page. 1157 - 1159, 2007-01
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김만주KIM, MAHN JOO
Dept of Chemistry
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