DC Field | Value | Language |
---|---|---|
dc.contributor.author | Youn, JI | - |
dc.contributor.author | Park, SH | - |
dc.contributor.author | Jin, HT | - |
dc.contributor.author | Lee, CG | - |
dc.contributor.author | Seo, SH | - |
dc.contributor.author | Song, MY | - |
dc.contributor.author | Lee, CW | - |
dc.contributor.author | Sung, YC | - |
dc.date.accessioned | 2016-04-01T01:08:47Z | - |
dc.date.available | 2016-04-01T01:08:47Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2008-11 | - |
dc.identifier.issn | 0929-1903 | - |
dc.identifier.other | 2008-OAK-0000008201 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/22469 | - |
dc.description.abstract | Protein transduction domains (PTDs) are small peptides that facilitate the transduction of large molecules such as polyproteins, DNA and viruses into a eukaryotic cell. Here, we demonstrated that a novel PTD (HP4) derived from herring protamine appeared to enter C6Bu1 rat glioma cell lines more rapidly than other known PTDs such as Tat, Antp and Hph-1. Moreover, HP4 significantly enhanced in vitro transduction of recombinant adenoviruses (rAds) into various cancer cell lines, mesenchymal stem cells (MSCs) and dendritic cells, which are relatively resistant to rAd infection. Enhancement of rAd delivery into C6Bu1 and MSCs by HP4 is 20 and 7 times higher than that by Tat, respectively. The increase in the expression of rAd encoding IL-12N220L by HP4 is proportional to its antitumor effect in the ex vivo transduced mouse colon cancer model. Thus, these results suggest that HP4 could be utilized to improve the transduction efficiency of rAd, resulting in enhanced efficacy of rAd-mediated gene therapy, especially for ex vivo-transduced cell therapy. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | CANCER GENE THERAPY | - |
dc.subject | protein transduction domains | - |
dc.subject | HP4 | - |
dc.subject | recombinant adenovirus | - |
dc.subject | INTRACELLULAR PROTEIN DELIVERY | - |
dc.subject | ARGININE-RICH PEPTIDES | - |
dc.subject | MEDIATED GENE-TRANSFER | - |
dc.subject | IN-VIVO | - |
dc.subject | CELLULAR UPTAKE | - |
dc.subject | ANTENNAPEDIA HOMEODOMAIN | - |
dc.subject | TRANSDUCTION DOMAINS | - |
dc.subject | PERMEABLE PEPTIDES | - |
dc.subject | 3RD HELIX | - |
dc.subject | MEMBRANE | - |
dc.title | Enhanced delivery efficiency of recombinant adenovirus into tumor and mesenchymal stem cells by a novel PTD | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1038/CGT.2008.45 | - |
dc.author.google | Youn, JI | - |
dc.author.google | Park, SH | - |
dc.author.google | Jin, HT | - |
dc.author.google | Lee, CG | - |
dc.author.google | Seo, SH | - |
dc.author.google | Song, MY | - |
dc.author.google | Lee, CW | - |
dc.author.google | Sung, YC | - |
dc.relation.volume | 15 | - |
dc.relation.issue | 11 | - |
dc.relation.startpage | 703 | - |
dc.relation.lastpage | 712 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | CANCER GENE THERAPY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CANCER GENE THERAPY, v.15, no.11, pp.703 - 712 | - |
dc.identifier.wosid | 000259826900002 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 712 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 703 | - |
dc.citation.title | CANCER GENE THERAPY | - |
dc.citation.volume | 15 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-53549090429 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 29 | - |
dc.description.scptc | 25 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INTRACELLULAR PROTEIN DELIVERY | - |
dc.subject.keywordPlus | ARGININE-RICH PEPTIDES | - |
dc.subject.keywordPlus | MEDIATED GENE-TRANSFER | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CELLULAR UPTAKE | - |
dc.subject.keywordPlus | ANTENNAPEDIA HOMEODOMAIN | - |
dc.subject.keywordPlus | TRANSDUCTION DOMAINS | - |
dc.subject.keywordPlus | PERMEABLE PEPTIDES | - |
dc.subject.keywordPlus | 3RD HELIX | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordAuthor | protein transduction domains | - |
dc.subject.keywordAuthor | HP4 | - |
dc.subject.keywordAuthor | recombinant adenovirus | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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