COMPARABLE STRUCTURAL STABILITIES OF PENTA-COORDINATE AND HEXA-COORDINATE ZN(II) IN A SIMPLE-MODEL SYSTEM OF THE ACTIVE-SITE OF CARBOXYPEPTIDASE-A
SCIE
- Title
- COMPARABLE STRUCTURAL STABILITIES OF PENTA-COORDINATE AND HEXA-COORDINATE ZN(II) IN A SIMPLE-MODEL SYSTEM OF THE ACTIVE-SITE OF CARBOXYPEPTIDASE-A
- Authors
- CHO, SJ; KIM, HS; KIM, KS; LEE, S; PARK, JK
- Date Issued
- 1994-09-20
- Publisher
- KOREAN CHEMICAL SOC
- Abstract
- Ab initio studies of simple model systems for the carboxypeptidase A active site indicate that penta- and hexa-coordinate Zn(II) complexes have comparable structural stabilities. These facile coordination structures can be responsible for the catalytic role. Although the hexa-coordinate Zn(II) complex is more stable in enthalpy than the penta-coordinate Zn(II) complex, the entropy effect makes the latter as stable as or slightly more stable in free energy than the former.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/21901
- ISSN
- 0253-2964
- Article Type
- Article
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 15, no. 9, page. 774 - 776, 1994-09-20
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