The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
SCIE
SCOPUS
- Title
- The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
- Authors
- Fata, JE; Kong, YY; Li, J; Sasaki, T; Irie-Sasaki, J; Moorehead, RA; Elliott, R; Scully, S; Voura, EB; Lacey, DL; Boyle, WJ; Khokha, R; Penninger, JM
- Date Issued
- 2000-09-29
- Publisher
- CELL PRESS
- Abstract
- Osteoprotegerin-ligand (OPGL) is a key osteoclast differentiation/activation factor essential for bone remodeling. We report that mice lacking OPGL or its receptor RANK fail to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Transplantation and OPGL-rescue experiments in opgl(-/-) and rank(-/-) pregnant females showed that OPGL acts directly on RANK-expressing mammary epithelial cells. The effects of OPGL are autonomous to epithelial cells. The mammary gland defect in female opgl(-/-) mice is characterized by enhanced apoptosis and failures in proliferation and PKB activation in lobulo-alveolar buds that can be reversed by recombinant OPGL treatment. These data provide a novel paradigm in mammary gland development and an evolutionary rationale for hormonal regulation and gender bias of osteoporosis in females.
- Keywords
- T-CELLS; RECEPTOR; MICE; PROLACTIN; PREGNANCY; LACTATION; PROTEIN; MOUSE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/19841
- DOI
- 10.1016/S0092-8674(00)00103-3
- ISSN
- 0092-8674
- Article Type
- Article
- Citation
- CELL, vol. 103, no. 1, page. 41 - 50, 2000-09-29
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- There are no files associated with this item.
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