Open Access System for Information Sharing

Login Library

 

REVIEW
Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Dynamic kinetic resolutions and asymmetric transformations by enzymes coupled with metal catalysis

Title
Dynamic kinetic resolutions and asymmetric transformations by enzymes coupled with metal catalysis
Authors
Kim, MJAhn, YPark, J박재욱
Date Issued
2002-12
Publisher
CURRENT BIOLOGY LTD
Abstract
The combination of enzyme and metal catalysis is described as a useful method for the synthesis of optically active compounds. A key feature of this new methodology is the use of metal catalysts for the in situ racemization of enzymatically unreactive enantiomers in the enzymatic resolution of racemic substrates. So far, two combinations - lipase-ruthenium and lipase-palladium - have been developed for the efficient dynamic kinetic resolution of alcohols and amines. The use of these combinations has also been extended to catalysis of the asymmetric transformation of ketones, their enol acetates, and ketoximes. In most cases, enzyme-metal combination catalysis has provided good yields and high optical purities.
Keywords
SECONDARY ALCOHOLS; ENZYMATIC RESOLUTION; CHIRAL ACETATES; AMINO ALCOHOLS; ENOL ACETATES; RACEMIZATION; LIPASE; PALLADIUM; KETONES; ROUTE
URI
https://oasis.postech.ac.kr/handle/2014.oak/18792
ISSN
0958-1669
Article Type
REVIEW
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Views & Downloads

Browse