Human hnRNP L shuttles between nucleus and cytoplasm
SCIE
SCOPUS
- Title
- Human hnRNP L shuttles between nucleus and cytoplasm
- Authors
- Lee, SY; Jang, SK; Choi, M
- Date Issued
- 2003-06
- Publisher
- GENETICS SOC KOREA
- Abstract
- The heterogeneous nuclear ribonucleoprotein L (hnRNP L) is an abundant nuclear protein and one of the major pre-mRNA binding proteins. It is a 68kD protein and contains 558 amino acid residues and four loosely conserved RNP-concensus RNA-binding domains. Recently published data suggest that hnRNP L plays roles on cytoplasmic functions, such as mRNA turnover and regulation of translation. In this study, we investigated the nucleo-cytoplasmic shuttling activity of hnRNP L using transient transfection in conjunction with interspecies heterokaryon assays. Here, we report that hnRNP L; although it is localized primarily in the nucleoplasm, shuttles between nucleus and cytoplasm. The hnRNP L protein is detected mainly in the nucleoplasm by immunofluorescence microscopy, presumably because the return of hnRNP L to the nucleus is very rapid.
- Keywords
- heterogeneous nuclear ribonucleoproteins (hnRNPs); RNP-concensus RNA-binding domain; nucleo-cytoplasmic shuttling activity; RNA-BINDING-PROTEINS; MESSENGER-RNA; EXPRESSION; SEQUENCE; EXPORT; SIGNAL; GENE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/18457
- ISSN
- 0254-5934
- Article Type
- Article
- Citation
- KOREAN JOURNAL OF GENETICS, vol. 25, no. 2, page. 141 - 145, 2003-06
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