(R)-Lipo-Diaza-18-Crown-6 Self-Assembled Monolayer as a Selective Serotonin Receptor
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SCOPUS
- Title
- (R)-Lipo-Diaza-18-Crown-6 Self-Assembled Monolayer as a Selective Serotonin Receptor
- Authors
- Park, JY; Lee, YS; Chang, BY; Karthikeyan, S; Kim, KS; Kim, BH; Park, SM
- Date Issued
- 2009-05-15
- Publisher
- AMER CHEMICAL SOC
- Abstract
- A highly selective receptor for serotonin was designed using cages formed by the (R)-lipo-diaza-18-crown-6 self-assembled monolayer (SAM) on gold and experimentally verified by a variety of electrochemical experiments in solutions containing large amounts of dopamine and ascorbic acid, as well as other interferents. The molecular modeling study showed that parameters such as the H-pi interaction provided important driving forces for the cage to form a strong inclusion complex with serotonin. The charge-transfer resistance (R-CT's) to/from redox probe ions, Fe(CN)(6)(3-5-), was greatly enhanced because of their electrostatic attractions to ammonium ions of serotonin molecules captured by cages. The changes in R-CT-values were shown to be remarkably selective for serotonin in the presence of many interferents.
- Keywords
- ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; SCAN CYCLIC VOLTAMMETRY; LABEL-FREE DETECTION; FOURIER-TRANSFORM; ELECTRON-TRANSFER; RAT-BRAIN; THIOLATED CYCLODEXTRIN; FLUORESCENCE DETECTION; LIQUID-CHROMATOGRAPHY; NUCLEUS-ACCUMBENS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/17594
- DOI
- 10.1021/AC900220N
- ISSN
- 0003-2700
- Article Type
- Article
- Citation
- ANALYTICAL CHEMISTRY, vol. 81, no. 10, page. 3843 - 3850, 2009-05-15
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- There are no files associated with this item.
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