Performance benchmarks of an array-based hand-held photoacoustic probe adapted from a clinical ultrasound system for non-invasive sentinel lymph node imaging
SCIE
SCOPUS
- Title
- Performance benchmarks of an array-based hand-held photoacoustic probe adapted from a clinical ultrasound system for non-invasive sentinel lymph node imaging
- Authors
- Kim, C; Erpelding, TN; Jankovic, L; Wang, LV
- Date Issued
- 2011-11-28
- Publisher
- The Royal Society
- Abstract
- Clinical translation of photoacoustic (PA) imaging can be facilitated by integration with commercial ultrasound (US) scanners to enable dual-modality imaging. An array-based US scanner was modified for hand-held PA imaging. The performance was benchmarked in terms of signal-to-noise ratio (SNR), axial spatial resolution and sensitivity. PA images of a tube, filled with methylene blue (MB; approx. 30mM) and placed at various depths in chicken tissue, were acquired. A 5 cm penetration depth was achieved with an 18.6 dB SNR using a laser fluence of 3mJcm(-2), only one-seventh of the safety limit (20mJcm(-2)). An axial resolution of approximately 400 mu m was maintained at all imaging depths. The PA sensitivity to MB placed 2.3 cm deep in chicken tissue was less than 100 mu M. Further, after intradermal injection of MB (approx. 30 mM), a rat sentinel lymph node was clearly identified in vivo, beneath a 3.8 cm thick layer of chicken breast. The accumulated concentration of MB in the node was estimated to be approximately 7mM. The noise-equivalent sensitivities (approx. 2 cm depth) were 17 and 85 mu M, ex vivo and in vivo, respectively. These results support the use of this PA system for non-invasive mapping and image-guided needle biopsy of sentinel nodes in breast cancer patients.
- Keywords
- photoacoustic imaging; clinical ultrasound array system; sentinel lymph node biopsy; image-guided needle biopsy; IN-VIVO; TOMOGRAPHY; TISSUE; BREAST
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/15414
- DOI
- 10.1098/rsta.2010.0353
- ISSN
- 1364-503X
- Article Type
- Article
- Citation
- PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, vol. 369, no. 1955, page. 4644 - 4650, 2011-11-28
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.