Mn2+-doped silica nanoparticles for hepatocyte-targeted detection of liver cancer in T-1-weighted MRI
SCIE
SCOPUS
- Title
- Mn2+-doped silica nanoparticles for hepatocyte-targeted detection of liver cancer in T-1-weighted MRI
- Authors
- Kim, SM; Im, GH; Lee, DG; Lee, JH; Lee, WJ; Lee, IS
- Date Issued
- 2013-11
- Publisher
- ELSEVIER SCI LTD
- Abstract
- With an aim to examine the possibility of developing a liver-specific MRI contrast agent that takes advantages of brightly enhanced MR images by Mn2+ whilst making up the limitations of the pre-developed contrast agent, the Mn2+-doped SiO2 nanoparticles (Mn-SiO2) were synthesized and their characteristics as MR contrast agents were investigated. The in vitro and in vivo investigations showed that Mn-SiO2 has unique MR contrast-enhancing characteristics that activate positive contrast enhancement in T-1-weighted MR images only under low pH conditions by liberating Mn2+ ions from MR inactive nanoparticles. The administration of Mn-SiO2 to an orthotopic xenograft model of human hepatocellular carcinoma (HCC) resulted in a differentiation of enhancement periods between HCC and normal parenchyma tissues on T-1-weighted MR images and consequently presented the duplicates of the highly contrast-enhanced liver image with an equal liver-to-HCC contrast ratio but opposite contrast. The Mn-SiO2-enhanced MR imaging therefore allowed for the repetitive detection of the HCC within a single MR imaging session, which can help us to achieve more reliable diagnosis and characterization of liver lesions than is possible with any currently used Mn2+-based contrast agent. In addition, the in vivo biodistribution study also supported the effectiveness of Mn-SiO2 nanoparticles as a liver-specific MRI contrast agent, which efficiently delivers and releases the T-1-contrasting Mn2+ ions to targeted hepatocytes. (C) 2013 Elsevier Ltd. All rights reserved.
- Keywords
- Nanoparticle; MRI (magnetic resonance imaging); Contrast agent; Liver; Manganese; Silica; MANGANESE OXIDE NANOPARTICLES; NEPHROGENIC SYSTEMIC FIBROSIS; SUPERPARAMAGNETIC IRON-OXIDE; IN-VIVO BIODISTRIBUTION; CONTRAST AGENTS; HEPATOCELLULAR-CARCINOMA; CELLULAR MRI; MNDPDP; PHARMACOKINETICS; NANOCRYSTALS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/15171
- DOI
- 10.1016/J.BIOMATERIALS.2013.08.009
- ISSN
- 0142-9612
- Article Type
- Article
- Citation
- BIOMATERIALS, vol. 34, no. 35, page. 8941 - 8948, 2013-11
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