Au-Cu2-xSe Heterodimer Nanoparticles with Broad Localized Surface Plasmon Resonance as Contrast Agents for Deep Tissue Imaging
SCIE
SCOPUS
- Title
- Au-Cu2-xSe Heterodimer Nanoparticles with Broad Localized Surface Plasmon Resonance as Contrast Agents for Deep Tissue Imaging
- Authors
- Liu, X; Lee, C; Law, WC; Zhu, DW; Liu, MX; Jeon, M; Kim, J; Prasad, PN; Kim, C; Swihart, MT
- Date Issued
- 2013-09
- Publisher
- ACS
- Abstract
- We report a new type of heterogeneous nanoparticles (NPs) composed of a heavily doped semiconductor domain (Cu2-xSe) and a metal domain (Au), which exhibit a broad localized surface plasmon resonance (LSPR) across visible and near-infrared (NIR) wavelengths, arising from interactions between the two nanocrystal domains. We demonstrate both in vivo photoacoustic imaging and in vitro dark field imaging, using the broad LSPR in Cu2-xSe-Au hybrid NPs to achieve contrast at different wavelengths. The high photoacoustic imaging, depth achieved, up to 17 mm, shows that these novel contrast agents could be clinically relevant. More broadly, this work demonstrates a new strategy for tuning LSPR absorbance by engineering the density of free charge carriers in two interacting domains.
- Keywords
- Localized surface plasmon resonance; heavily doped semiconductor; photoacoustic imaging; metal nanoparticles; contrast agent; FLUORESCENT BIOLOGICAL LABELS; PHOTOTHERMAL CANCER-THERAPY; SEMICONDUCTOR QUANTUM RODS; NEAR-INFRARED LIGHT; BRAINS IN-VIVO; GOLD NANOCAGES; PHOTOACOUSTIC TOMOGRAPHY; HYBRID NANOPARTICLES; CU2-XSE NANOCRYSTALS; DOTS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/14864
- DOI
- 10.1021/NL402124H
- ISSN
- 1530-6984
- Article Type
- Article
- Citation
- NANO LETTERS, vol. 13, no. 9, page. 4333 - 4339, 2013-09
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.