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T Cell Receptor-Dependent Regulation of Lipid Rafts Controls Naive CD8(+) T Cell Homeostasis SCIE SCOPUS

Title
T Cell Receptor-Dependent Regulation of Lipid Rafts Controls Naive CD8(+) T Cell Homeostasis
Authors
Cho, JHKim, HOSurh, CDSprent, J
Date Issued
2010-02-26
Publisher
Cell Press
Abstract
T cell receptor (TCR) contact with self ligands keeps T cells alive and is shown here to cause naive CD8(+), but not CD4(+), T cells to be hypersensitive to certain gamma(c) cytokines, notably interleukin (IL)-2, IL-15, and IL-7. Hypersensitivity of CD8(+) T cells to IL-2 was dependent on a low-level TCR signal, associated with high expression of CD5 and GM1, a marker for lipid rafts, and was abolished by disruption of lipid rafts. By contrast, CD4(+) T cells expressed low amounts of GM1 and were unresponsive to IL-2. Physiologically, sensitivity to IL-7 and IL-15 maintains survival of resting CD8(+) T cells, whereas sensitivity to IL-2 may be irrelevant for normal homeostasis but crucial for the immune response. Thus, TCR contact with antigen upregulates GM1 and amplifies responsiveness of naive CD8(+) T cells to IL-2, thereby making the cells highly sensitive to exogenous IL-2 from CD4(+) T helper cells.
Keywords
SIGNAL-TRANSDUCTION; SENSORY ADAPTATION; IL-2 RECEPTOR; TCR AVIDITY; IN-VIVO; MEMORY; PROLIFERATION; DIFFERENTIATION; RESPONSES; SELECTION
URI
https://oasis.postech.ac.kr/handle/2014.oak/14750
DOI
10.1016/J.IMMUNI.2009.11.014
ISSN
1074-7613
Article Type
Article
Citation
Immunity, vol. 32, no. 2, page. 214 - 226, 2010-02-26
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SURH CHARLES DSURH, CHARLES D
Div of Integrative Biosci & Biotech
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