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Cited 4 time in webofscience Cited 5 time in scopus
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dc.contributor.authorJu-Won Kwak-
dc.contributor.authorHyobin Jeong-
dc.contributor.authorSun-Ho Han-
dc.contributor.authorYoungkyu Kim-
dc.contributor.authorSung Min Son-
dc.contributor.authorInhee Mook-Jung-
dc.contributor.authorDaehee Hwang-
dc.contributor.authorPark, JW-
dc.date.accessioned2015-06-25T03:25:43Z-
dc.date.available2015-06-25T03:25:43Z-
dc.date.created2014-12-01-
dc.date.issued2014-05-06-
dc.identifier.issn1932-6203-
dc.identifier.other2015-OAK-0000030481en_US
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/12702-
dc.description.abstractMonitoring protein phosphorylation at the cellular level is important to understand the intracellular signaling. Among the phosphoproteomics methods, phosphokinase antibody arrays have emerged as preferred tools to measure well-characterized phosphorylation in the intracellular signaling. Here, we present a dendron-coated phosphokinase antibody array (DPA) in which the antibodies are immobilized on a dendron-coated glass slide. Self-assembly of conically shaped dendrons well-controlled in size and structure resulted in precisely controlled lateral spacing between the immobilized phosphosite-specific antibodies, leading to minimized steric hindrance and improved antigen-antibody binding kinetics. These features increased sensitivity, selectivity, and reproducibility in measured amounts of protein phosphorylation. To demonstrate the utility of the DPA, we generated the phosphorylation profiles of brain tissue samples obtained from Alzheimer's disease (AD) model mice. The analysis of the profiles revealed signaling pathways deregulated during the course of AD progression.-
dc.description.statementofresponsibilityopenen_US
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsBY_NC_NDen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/kren_US
dc.titlePhosphokinase antibody arrays on dendron-coated surface-
dc.typeArticle-
dc.contributor.college화학과en_US
dc.identifier.doi10.1371/JOURNAL.PONE.0096456-
dc.author.googleKwak, JWen_US
dc.author.googleJeong, Hen_US
dc.author.googlePark, JWen_US
dc.author.googleHwang, Den_US
dc.author.googleMook-Jung, Ien_US
dc.author.googleSon, SMen_US
dc.author.googleKim, Yen_US
dc.author.googleHan, SHen_US
dc.relation.volume9en_US
dc.relation.issue5en_US
dc.relation.startpageE96456en_US
dc.contributor.id10053210en_US
dc.relation.journalPLOS ONEen_US
dc.relation.indexSCI급, SCOPUS 등재논문en_US
dc.relation.sciSCIen_US
dc.collections.nameJournal Papersen_US
dc.type.rimsART-
dc.identifier.bibliographicCitationPLOS ONE, v.9, no.5, pp.E96456-
dc.identifier.wosid000338029800070-
dc.date.tcdate2019-01-01-
dc.citation.number5-
dc.citation.startPageE96456-
dc.citation.titlePLOS ONE-
dc.citation.volume9-
dc.contributor.affiliatedAuthorJu-Won Kwak-
dc.contributor.affiliatedAuthorPark, JW-
dc.identifier.scopusid2-s2.0-84900426234-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.wostc3-
dc.description.scptc3*
dc.date.scptcdate2018-10-274*
dc.type.docTypeArticle-
dc.subject.keywordPlusPROTEIN MICROARRAYS-
dc.subject.keywordPlusMASS-SPECTROMETRY-
dc.subject.keywordPlusLIGHT-CHAINS-
dc.subject.keywordPlusPHOSPHORYLATION-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusDATABASE-
dc.subject.keywordPlusPATHWAYS-
dc.subject.keywordPlusCLONING-
dc.subject.keywordPlusKINASE-
dc.subject.keywordPlusMEMORY-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-

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