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Cited 11 time in webofscience Cited 13 time in scopus
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dc.contributor.authorEunjin Hwang-
dc.contributor.authorKim, S-
dc.contributor.authorKyungreem Han-
dc.contributor.authorJee Hyun Choi-
dc.date.accessioned2015-06-25T03:24:07Z-
dc.date.available2015-06-25T03:24:07Z-
dc.date.created2014-03-06-
dc.date.issued2012-12-07-
dc.identifier.issn1932-6203-
dc.identifier.other2015-OAK-0000029215en_US
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/12661-
dc.description.abstractThe thalamocortical system plays a key role in the breakdown or emergence of consciousness, providing bottom-up information delivery from sensory afferents and integrating top-down intracortical and thalamocortical reciprocal signaling. A fundamental and so far unanswered question for cognitive neuroscience remains whether the thalamocortical switch for consciousness works in a discontinuous manner or not. To unveil the nature of thalamocortical system phase transition in conjunction with consciousness transition, ketamine/xylazine was administered unobtrusively to ten mice under a forced working test with motion tracker, and field potentials in the sensory and motor-related cortex and thalamic nuclei were concomitantly collected. Sensory and motor-related thalamocortical networks were found to behave continuously at anesthesia induction and emergence, as evidenced by a sigmoidal response function with respect to anesthetic concentration. Hyperpolarizing and depolarizing susceptibility diverged, and a non-discrete change of transitional probability occurred at transitional regimes, which are hallmarks of continuous phase transition. The hyperpolarization curve as a function of anesthetic concentration demonstrated a hysteresis loop, with a significantly higher anesthetic level for transition to the down state compared to transition to the up state. Together, our findings concerning the nature of phase transition in the thalamocortical system during consciousness transition further elucidate the underlying basis for the ambiguous borderlines between conscious and unconscious brains. Moreover, our novel analysis method can be applied to systematic and quantitative handling of subjective concepts in cognitive neuroscience.-
dc.description.statementofresponsibilityopenen_US
dc.languageEnglish-
dc.publisherPLOS-
dc.relation.isPartOfPLOS One-
dc.rightsBY_NC_NDen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/kren_US
dc.titleCharacterization of Phase Transition in the Thalamocortical System during Anesthesia-Induced Loss of Consciousness-
dc.typeArticle-
dc.contributor.college물리학과en_US
dc.identifier.doi10.1371/JOURNAL.PONE.0050580-
dc.author.googleHwang, Een_US
dc.author.googleKim, Sen_US
dc.author.googleChoi, JHen_US
dc.author.googleHan, Ken_US
dc.relation.volume7en_US
dc.relation.issue12en_US
dc.contributor.id10054190en_US
dc.relation.journalPLOS Oneen_US
dc.relation.indexSCI급, SCOPUS 등재논문en_US
dc.relation.sciSCIen_US
dc.collections.nameJournal Papersen_US
dc.type.rimsART-
dc.identifier.bibliographicCitationPLOS One, v.7, no.12-
dc.identifier.wosid000312064100021-
dc.date.tcdate2019-01-01-
dc.citation.number12-
dc.citation.titlePLOS One-
dc.citation.volume7-
dc.contributor.affiliatedAuthorKim, S-
dc.identifier.scopusid2-s2.0-84870891991-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.wostc8-
dc.description.scptc9*
dc.date.scptcdate2018-10-274*
dc.type.docTypeArticle-
dc.subject.keywordPlusCORTICAL EFFECTIVE CONNECTIVITY-
dc.subject.keywordPlusGENERAL-ANESTHESIA-
dc.subject.keywordPlusSPECTRAL EDGE-
dc.subject.keywordPlusBREAKDOWN-
dc.subject.keywordPlusPROPOFOL-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusSTATE-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-

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