Complexation and conjugation approaches to evaluate siRNA delivery using cationic, hydrophobic and amphiphilic peptides
SCIE
SCOPUS
- Title
- Complexation and conjugation approaches to evaluate siRNA delivery using cationic, hydrophobic and amphiphilic peptides
- Authors
- Park, JW; Bang, EK; Jeon, EM; Kim, BH
- Date Issued
- 2012-01
- Publisher
- Royal Society of Chemistry
- Abstract
- In this study, we used solid phase synthesis to prepare three kinds of peptides and then formulated their peptide-siRNA complexes and peptide-siRNA conjugates. Both the complexation and conjugation systems were nontoxic and allowed the delivery of siRNA into the cytoplasm without the need for any transfection agents and with subsequent inhibition of gene expression.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/11883
- DOI
- 10.1039/C1OB06042B
- ISSN
- 1477-0520
- Article Type
- Article
- Citation
- ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 10, no. 1, page. 96 - 102, 2012-01
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