Cationic nucleolipids as efficient siRNA carriers
SCIE
SCOPUS
- Title
- Cationic nucleolipids as efficient siRNA carriers
- Authors
- Yang, HW; Yi, JW; Bang, EK; Jeon, EM; Kim, BH
- Date Issued
- 2011-01
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- We synthesized five novel uridine-based cationic nucleolipids, introducing basic amino acid residues at the 5 ' position of uridine, through 1,3-dipolar cycloaddition, and hydrophobic alkyl moieties at the 2 ' and 3 ' positions, through carbamate linkages. Their lipoplexes delivered siRNAs efficiently to cells, in vitro, without any severe toxicity.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/11879
- DOI
- 10.1039/C0OB00580K
- ISSN
- 1477-0520
- Article Type
- Article
- Citation
- ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 9, no. 1, page. 291 - 296, 2011-01
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