Novel molecular drug carrier: encapsulation of oxaliplatin in cucurbit[7]uril and its effects on stability and reactivity of the drug
SCIE
SCOPUS
- Title
- Novel molecular drug carrier: encapsulation of oxaliplatin in cucurbit[7]uril and its effects on stability and reactivity of the drug
- Authors
- Jeon, YJ; Kim, SY; Ko, YH; Sakamoto, S; Yamaguchi, K; Kim, K
- Date Issued
- 2005-01
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- Oxaliplatin forms a stable 1 : 1 inclusion complex with cucurbit[7] uril as indicated by NMR, mass spectrometry, isothermal titration calorimetry and X-ray crystallography. The encapsulation of the drug results in a large enhancement in stability, a moderate decrease in reactivity toward guanosine but a much larger decrease in reactivity toward L-methionine, which suggests the encapsulation not only increases the stability of the drug but also may reduce unwanted side effects caused by protein binding of the platinum drug. A preliminary in vitro assay using various tumor cell lines reveals that the encapsulation results in a decrease in the antitumor activity of oxaliplatin.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/11873
- DOI
- 10.1039/B504487A
- ISSN
- 1477-0520
- Article Type
- Article
- Citation
- ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 3, no. 11, page. 2122 - 2125, 2005-01
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