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Cited 129 time in webofscience Cited 119 time in scopus
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Depression research: where are we now? SCIE SCOPUS

Title
Depression research: where are we now?
Authors
Lee, SJeong, JKwak, YPark, SK
Date Issued
2010-03
Publisher
BioMed Central
Abstract
Extensive studies have led to a variety of hypotheses for the molecular basis of depression and related mood disorders, but a definite pathogenic mechanism has yet to be defined. The monoamine hypothesis, in conjunction with the efficacy of antidepressants targeting monoamine systems, has long been the central topic of depression research. While it is widely embraced that the initiation of antidepressant efficacy may involve acute changes in monoamine systems, apparently, the focus of current research is moving toward molecular mechanisms that underlie long-lasting downstream changes in the brain after chronic antidepressant treatment, thereby reaching for a detailed view of the pathophysiology of depression and related mood disorders. In this minireview, we briefly summarize major themes in current approaches to understanding mood disorders focusing on molecular views of depression and antidepressant action.
URI
https://oasis.postech.ac.kr/handle/2014.oak/11721
DOI
10.1186/1756-6606-3-8
ISSN
1756-6606
Article Type
Article
Citation
MOLECULAR BRAIN, vol. 3, no. 1, page. 8 - 17, 2010-03
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박상기PARK, SANG KI
Dept of Life Sciences
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