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Cited 28 time in webofscience Cited 31 time in scopus
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dc.contributor.authorLee, B-
dc.contributor.authorKim, SG-
dc.contributor.authorKim, J-
dc.contributor.authorChoi, KY-
dc.contributor.authorLee, S-
dc.contributor.authorLee, SK-
dc.contributor.authorLee, JW-
dc.date.accessioned2015-06-25T02:49:30Z-
dc.date.available2015-06-25T02:49:30Z-
dc.date.created2013-07-02-
dc.date.issued2013-07-
dc.identifier.issn0270-7306-
dc.identifier.other2015-OAK-0000027728en_US
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/11702-
dc.description.abstractThe molecular basis underlying the physiologically well-defined orexigenic function of glucocorticoid (Gc) is unclear. Brain-specific homeobox factor (Bsx) is a positive regulator of the orexigenic neuropeptide, agouti-related peptide (AgRP), in AgRP neurons of the hypothalamic arcuate nucleus. Here, we show that in response to fasting-elevated Gc levels, Gc receptor (GR) and Bsx synergize to direct activation of AgRP transcription. This synergy is dictated by unique sequence features in a novel Gc response element in AgRP (AgRP-GRE). In contrast to AgRP-GRE, Bsx suppresses transactivation directed by many conventional GREs, functioning as a gene context-dependent modulator of GR actions or a target selector for GR. Consistent with this finding, AgRP-GRE drives fasting-dependent activation of a target gene specifically in GR(+) Bsx(+) AgRP neurons. These results define AgRP as a common orexigenic target gene of GR and Bsx and provide an opportunity to identify their additional common targets, facilitating our understanding of the molecular basis underlying the orexigenic activity of Gc and Bsx.-
dc.description.statementofresponsibilityopenen_US
dc.languageEnglish-
dc.publisherAMER SOC MICROBIOLOGY-
dc.relation.isPartOfMolecular and cellular biology-
dc.rightsBY_NC_NDen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/kren_US
dc.titleBrain-Specific Homeobox Factor as a Target Selector for Glucocorticoid Receptor in Energy Balance.-
dc.typeArticle-
dc.contributor.college융합생명공학부en_US
dc.identifier.doi10.1128/MCB.00094-13-
dc.author.googleLee, Ben_US
dc.author.googleKim, SGen_US
dc.author.googleLee, JWen_US
dc.author.googleLee, SKen_US
dc.author.googleLee, Sen_US
dc.author.googleChoi, KYen_US
dc.author.googleKim, Jen_US
dc.relation.volume14en_US
dc.relation.issue33en_US
dc.relation.startpage2650en_US
dc.relation.lastpage2658en_US
dc.contributor.id10052985en_US
dc.relation.journalMolecular and cellular biologyen_US
dc.relation.indexSCI급, SCOPUS 등재논문en_US
dc.relation.sciSCIen_US
dc.collections.nameJournal Papersen_US
dc.type.rimsART-
dc.identifier.bibliographicCitationMolecular and cellular biology, v.14, no.33, pp.2650 - 2658-
dc.identifier.wosid000320714400001-
dc.date.tcdate2019-01-01-
dc.citation.endPage2658-
dc.citation.number33-
dc.citation.startPage2650-
dc.citation.titleMolecular and cellular biology-
dc.citation.volume14-
dc.contributor.affiliatedAuthorChoi, KY-
dc.identifier.scopusid2-s2.0-84880660350-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.wostc13-
dc.description.scptc13*
dc.date.scptcdate2018-10-274*
dc.type.docTypeArticle-
dc.subject.keywordPlusARCUATE NUCLEUS-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusNEUROPEPTIDE-Y-
dc.subject.keywordPlusBODY-WEIGHT-
dc.subject.keywordPlusFOOD-INTAKE-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusHOMEOSTASIS-
dc.subject.keywordPlusBSX-
dc.subject.keywordPlusLEPTIN-
dc.subject.keywordPlusSYSTEM-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaCell Biology-

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최관용CHOI, KWAN YONG
Div of Integrative Biosci & Biotech
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