Electrocatalytic Radical-Polar Crossover Hydroetherification of Alkenes with Phenols
SCIE
SCOPUS
- Title
- Electrocatalytic Radical-Polar Crossover Hydroetherification of Alkenes with Phenols
- Authors
- PARK, STEVE H; JANG, JIEUN; SHIN, KWANGMIN; KIM, HYUNWOO
- Date Issued
- 2022-09
- Publisher
- American Chemical Society
- Abstract
- We disclose a general electrocatalytic hydroetherification for modular synthesis of alkyl aryl ethers by utilizing a wide range of alkenes and phenols. The integration of the two involves an electrochemically instigated cobalt-hydride-catalyzed radical-polar crossover of alkenes that enable the generation of key cationic intermediates, which could readily be entrapped by challenging nucleophilic phenols. We highlight the importance of precise control of the reaction potential by electrochemistry in conjunction with the decisive role of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as the co-solvent to obtain optimal and exclusive chemoselectivity. This reaction system is pertinent to late-stage functionalization of pharmacophores that contain alkyl aryl ethers which have constantly been challenged since traditionally unconventional methods.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/116597
- DOI
- 10.1021/acscatal.2c02436
- ISSN
- 2155-5435
- Article Type
- Article
- Citation
- ACS Catalysis, vol. 12, no. 17, page. 10572 - 10580, 2022-09
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- There are no files associated with this item.
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