Self-illuminative cascade-reaction-driven anticancer therapeutic cassettes made of cooperatively interactive nanocomplexes
SCIE
SCOPUS
- Title
- Self-illuminative cascade-reaction-driven anticancer therapeutic cassettes made of cooperatively interactive nanocomplexes
- Authors
- Song, Woo Chul; Shin, Seung Won; Park, Kyung Soo; Jang, Min Su; Choi, Jin-Ha; Oh, Byung-Keun; Um, Soong Ho
- Date Issued
- 2015-02
- Publisher
- Elsevier BV
- Abstract
- Therapeutic options based on near-infrared (NIR) wavelengths have attracted attention owing to in vivo lowest-background interventions and the development of several nano-architectures with localized surface plasmon resonance. Because of their limited tissue penetration, the clinical use of NIR light-driven treatments is not widespread; this technology is inapplicable to infection sites in the deeper areas of internal tissues. In this study, we demonstrate a self-illuminative therapeutic cassette able to exert anticancer effects via a series of enzymatic, chemical, and optical cooperative cascade reactions. It consists of (1) NIR-illuminative nanocomplexes and (2) NIR-sensitive therapeutic cassettes, which demonstrate a 60% chemically-induced killing effect in a prostate cancer model without external NIR irradiation. This technology can also be actively exploited as an imaging agent due to adaptation of a self-illuminating nanocomplex. Consequently, these novel therapeutic cassettes, which work not only as a powerful internal NIR stimulant, but also as a biological imaging platform, provide a new rational design concept for biomedical use. © 2014 Elsevier B.V.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/116305
- DOI
- 10.1016/j.colsurfb.2014.12.011
- ISSN
- 0927-7765
- Article Type
- Article
- Citation
- Colloids and Surfaces B: Biointerfaces, vol. 126, page. 580 - 584, 2015-02
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