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3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration SCOPUS

Title
3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration
Authors
CHAE, SUHUNYONG, UIJUNGPARK, WONBINCHOI, YOO MIJEON, IN-HOKANG, HOMANJANG, JIN AHCHOI, HAK SOOCHO, DONG WOO
Date Issued
2023-01
Publisher
Elsevier
Abstract
Owing to the prevalence of rotator cuff (RC) injuries and suboptimal healing outcome, rapid and functional regeneration of the tendon–bone interface (TBI) after RC repair continues to be a major clinical challenge. Given the essential role of the RC in shoulder movement, the engineering of biomimetic multi-tissue constructs presents an opportunity for complex TBI reconstruction after RC repair. Here, we propose a gradient cell-laden multi-tissue construct combined with compositional gradient TBI-specific bioinks via 3D cell-printing technology. In vitro studies demonstrated the capability of a gradient scaffold system in zone-specific inducibility and multi-tissue formation mimicking TBI. The regenerative performance of the gradient scaffold on RC regeneration was determined using a rat RC repair model. In particular, we adopted nondestructive, consecutive, and tissue-targeted near-infrared fluorescence imaging to visualize the direct anatomical change and the intricate RC regeneration progression in real time in vivo. Furthermore, the 3D cell-printed implant promotes effective restoration of shoulder locomotion function and accelerates TBI healing in vivo. In summary, this study identifies the therapeutic contribution of cell-printed constructs towards functional RC regeneration, demonstrating the translational potential of biomimetic gradient constructs for the clinical repair of multi-tissue interfaces. © 2022 The Authors
URI
https://oasis.postech.ac.kr/handle/2014.oak/113024
DOI
10.1016/j.bioactmat.2022.05.004
ISSN
2452-199X
Article Type
Article
Citation
Bioactive Materials, vol. 19, page. 611 - 625, 2023-01
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조동우CHO, DONG WOO
Dept of Mechanical Enginrg
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