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The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling SCIE SCOPUS

Title
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
Authors
Brinkmann, MMSpooner, EHoebe, KBeutler, BPloegh, HLKim, YM
Date Issued
2007-04-23
Publisher
ROCKEFELLER UNIV PRESS
Abstract
Toll-like receptors (TLRs) sense the presence of microbial and viral pathogens by signal transduction mechanisms that remain to be fully elucidated. A single point mutation (H412R) in the polytopic endoplasmic reticulum (ER)-resident membrane protein UNC93B abolishes signaling via TLR3, 7, and 9. We show that UNC93B specifically interacts with TLR3, 7, 9, and 13, whereas introduction of the point mutation H412R in UNC93B abolishes their interactions. We establish the physical interaction of the intracellular TLRs with UNC93B in splenocytes and bone marrow-derived dendritic cells. Further, by expressing chimeric TLRs, we show that TLR3 and 9 bind to UNC93B via their transmembrane domains. We propose that a physical association between UNC93B and TLRs in the ER is essential for proper TLR signaling.
URI
https://oasis.postech.ac.kr/handle/2014.oak/10691
DOI
10.1083/JCB.200612056
ISSN
0021-9525
Article Type
Article
Citation
JOURNAL OF CELL BIOLOGY, vol. 177, no. 2, page. 265 - 275, 2007-04-23
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김유미KIM, YOU ME
Div of Integrative Biosci & Biotech
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