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Cited 27 time in webofscience Cited 23 time in scopus
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dc.contributor.authorChoi, J-
dc.contributor.authorPark, Y-
dc.contributor.authorChoi, EB-
dc.contributor.authorKim, HO-
dc.contributor.authorKim, DJ-
dc.contributor.authorHong, Y-
dc.contributor.authorRyu, SH-
dc.contributor.authorLee, JH-
dc.contributor.authorSuh, JS-
dc.contributor.authorYang, J-
dc.contributor.authorHuh, YM-
dc.contributor.authorHaam, S-
dc.date.accessioned2015-06-25T02:17:33Z-
dc.date.available2015-06-25T02:17:33Z-
dc.date.created2015-01-20-
dc.date.issued2014-05-
dc.identifier.issn1083-3668-
dc.identifier.other2015-OAK-0000030729en_US
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/10683-
dc.description.abstractBiomarker-specific photothermal nanoparticles that can efficiently sense markers that are overexpressed in distinguished adenocarcinomas have attracted much interest in an aspect of efficacy increase of cancer treatment. We demonstrated a promising prospect of a smart photothermal therapy agent employing anti-epidermal growth factor receptor aptamer (Apt(EGFR))-conjugated polyethylene glycol (PEG) layted gold nanorods (Apt(EGFR)-PGNRs). The cetyltrimethylammonium bromide bilayer on GNRs was replaced with heterobifunctional PEG (COOH-PEG-SH) not only to serve as a biocompatible stabilizer and but also to conjugate Apt(EGFR). Subsequently, to direct photothermal therapy agent toward epithelial cancer cells, the carboxylated PEGylated GNRs (PGNRs) were further functionalized with Apt(EGFR) using carbodiimide chemistry. Then, to assess the potential as biomarker-specific photothermal therapy agent of synthesized Apt(EGFR)-PGNRs, the optical properties, biocompatibility, colloidal stability, binding affinity, and epicellial cancer cell killing efficacy in vitro/in vivo under near-infrared laser irradiation were investigated. As a result, Apt(EGFR)-PGNRs exhibit excellent tumor targeting ability and feasibility of effective photothermal ablation cancer therapy. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)-
dc.description.statementofresponsibilityopenen_US
dc.languageEnglish-
dc.publisherJOURNAL OF BIOMEDICAL OPTICS-
dc.relation.isPartOfJOURNAL OF BIOMEDICAL OPTICS-
dc.rightsBY_NC_NDen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/kren_US
dc.titleAptamer-conjugated gold nanorod for photothermal ablation of epidermal growth factor receptor-overexpressed epithelial cancer-
dc.typeArticle-
dc.contributor.college생명과학과en_US
dc.identifier.doi10.1117/1.JBO.19.5.051203-
dc.author.googleChoi, Jen_US
dc.author.googlePark, Yen_US
dc.author.googleHaam, Sen_US
dc.author.googleHuh, YMen_US
dc.author.googleYang, Jen_US
dc.author.googleSuh, JSen_US
dc.author.googleLee, JHen_US
dc.author.googleRyu, SHen_US
dc.author.googleHong, Yen_US
dc.author.googleKim, DJen_US
dc.author.googleKim, HOen_US
dc.author.googleChoi, EBen_US
dc.relation.volume19en_US
dc.relation.issue5en_US
dc.contributor.id10069853en_US
dc.relation.journalJOURNAL OF BIOMEDICAL OPTICSen_US
dc.relation.indexSCI급, SCOPUS 등재논문en_US
dc.relation.sciSCIen_US
dc.collections.nameJournal Papersen_US
dc.type.rimsART-
dc.identifier.bibliographicCitationJOURNAL OF BIOMEDICAL OPTICS, v.19, no.5-
dc.identifier.wosid000338334600004-
dc.date.tcdate2019-01-01-
dc.citation.number5-
dc.citation.titleJOURNAL OF BIOMEDICAL OPTICS-
dc.citation.volume19-
dc.contributor.affiliatedAuthorRyu, SH-
dc.identifier.scopusid2-s2.0-84889841816-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.wostc10-
dc.description.scptc15*
dc.date.scptcdate2018-10-274*
dc.type.docTypeArticle-
dc.subject.keywordAuthoraptamer-
dc.subject.keywordAuthorgold nanorod-
dc.subject.keywordAuthorepithelial cancer-
dc.subject.keywordAuthorphotothermal therapy-
dc.subject.keywordAuthornear-infrared-
dc.relation.journalWebOfScienceCategoryBiochemical Research Methods-
dc.relation.journalWebOfScienceCategoryOptics-
dc.relation.journalWebOfScienceCategoryRadiology, Nuclear Medicine & Medical Imaging-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaOptics-
dc.relation.journalResearchAreaRadiology, Nuclear Medicine & Medical Imaging-

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류성호RYU, SUNG HO
Dept of Life Sciences
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