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Exfoliated bentonite/alginate nanocomposite hydrogel enhances intestinal delivery of probiotics by resistance to gastric pH and on-demand disintegration

Title
Exfoliated bentonite/alginate nanocomposite hydrogel enhances intestinal delivery of probiotics by resistance to gastric pH and on-demand disintegration
Authors
Kim, JihyunHlaing, Shwe PhyuLee, JuhoSaparbayeva, AruzhanKim, SangsikHwang, Dong SooLee, Eun HeeYoon, In-SooYun, HwayoungKim, Min-SooMoon, Hyung RyongJung, YunjinYoo, Jin-Wook
Date Issued
2021-11-15
Publisher
Pergamon Press Ltd.
Abstract
In this study, we developed Lactobacillus rhamnosus GG (LGG)-encapsulating exfoliated bentonite/alginate nanocomposite hydrogels for protecting probiotics by delaying gastric fluid penetration into the nanocomposite and their on-demand release in the intestine. The pore size of the bentonite/alginate nanocomposite hydrogels (BA15) was two-fold smaller than that of alginate hydrogel (BA00). Following gastric pH challenge, the survival of LGG in BA15 decreased by only 1.43 log CFU/g as compared to the 6.25 log CFU/g decrease in alginate (BA00). Further, the internal pH of BA15 decreased more gradually than that of BA00. After oral administration in mice, BA15 maintained shape integrity during gastric passage, followed by appropriate disintegration within the target intestinal area. Additionally, a fecal recovery experiment in mice showed that the viable counts of LGG in BA15 were six-fold higher than those in BA00. The findings suggest the exfoliated bentonite/alginate nanocomposite hydrogel as a promising platform for intestinal delivery of probiotics.
Keywords
ACID TOLERANCE RESPONSE; ALGINATE; MONTMORILLONITE; MICROENCAPSULATION; MICROBIOME; SURVIVAL; RELEASE; HEALTH
URI
/home/dspace/dspace56/handle/2014.oak/106787
ISSN
0144-8617
Article Type
Article
Citation
CARBOHYDRATE POLYMERS, vol. 272, 2021-11-15
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황동수HWANG, DONG SOO
Div of Environmental Science & Enginrg
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