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Biomimetic Janus chitin nanofiber membrane for potential guided bone regeneration application

Title
Biomimetic Janus chitin nanofiber membrane for potential guided bone regeneration application
Authors
Ekavianty PrajatelistiaNaresh D. SanandiyaAndrieanto NurrochmanFresty MarseliCHOY, SEUNGHWANHWANG, DONG SOO
Date Issued
1-Jan-2021
Publisher
ELSEVIER SCI LTD
Abstract
Biopolymer-based membranes are at the forefront of the guided bone regeneration (GBR) in orthopaedics and dentistry, which prevent fast-growing soft tissue migration to the defected alveolar ridge or implants and allow the bone regeneration. In this study, we fabricated a novel Janus -two-faced, GBR membrane composed of a chitin nanofiber face for bone regeneration and a cell membrane mimetic antifouling 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymeric face for suppressing the migration of the soft tissue. In vitro cell study showed a higher cell proliferation rate of osteoblast cells on the chitin nanofiber surface and a lower proliferation rate of fibroblasts cells on the antifouling MPC side. An increased of Alkaline Phosphatase (ALP) rate was observed in the chitin nanofiber face, indicating the ability to maintain proliferation and differentiation of osteogenic cells. These results suggest the biomimetic Janus chitin membrane may have the potential to develop as an advance GBR membrane.
Keywords
2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE; ADHESION; CHITOSAN; HYDROGEL; COHESION; BARRIER
URI
http://oasis.postech.ac.kr/handle/2014.oak/104538
ISSN
0144-8617
Article Type
Article
Citation
CARBOHYDRATE POLYMERS, vol. 251, 2021-01-01
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황동수HWANG, DONG SOO
Div of Environmental Science & Enginrg
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