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Urease-Powered Polydopamine Nanomotors for Intravesical Therapy of Bladder Diseases

Title
Urease-Powered Polydopamine Nanomotors for Intravesical Therapy of Bladder Diseases
Authors
Choi, Hyun SikCho, Seung HwiHAHN, SEI KWANG
Date Issued
Jun-2020
Publisher
AMER CHEMICAL SOC
Abstract
Intravesical therapeutic delivery has been extensively investigated for various bladder diseases such as bladder cancer, overactive bladder, urinary incontinence, and interstitial cystitis. However, conventional drug carriers have a low therapeutic delivery efficiency because of the passive diffusion of drug molecules in a bladder and the rapid clearance by periodic urination. Here, we report biocompatible and bioavailable enzyme-powered polymer nanomotors which can deeply penetrate into a mucosa layer of the bladder wall and remain for a long-term period in the bladder. The successful fabrication of nanomotors was confirmed by high-resolution transmission electron microscopy, energy-dispersive X-ray mapping, zetapotential analysis, Fourier transform infrared spectroscopy, and urease activity and nanomotor trajectory analyses. After injection into the bladder, urease-immobilized nanomotors became active, moving around in the bladder by converting urea into carbon dioxide and ammonia. The nanomotors resulted in the facilitated penetration to the mucosa layer of the bladder wall and the prolonged retention in the bladder even after repeated urination. The enhanced penetration and retention of the nanomotors as a drug delivery carrier in the bladder would be successfully harnessed for treating a variety of bladder diseases.
URI
http://oasis.postech.ac.kr/handle/2014.oak/103863
ISSN
1936-0851
Article Type
Article
Citation
ACS NANO, vol. 14, no. 6, page. 6683 - 6692, 2020-06
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한세광HAHN, SEI KWANG
Dept of Materials Science & Enginrg
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