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Structural features and immunological perception of the cell surface glycans of Lactobacillus plantarum: a novel rhamnose-rich polysaccharide and teichoic acids

Title
Structural features and immunological perception of the cell surface glycans of Lactobacillus plantarum: a novel rhamnose-rich polysaccharide and teichoic acids
Authors
Garcia-Vello, PilarSharma, GarimaSpeciale, ImmacolataMolinaro, AntonioIm, Sin-HyeogDe Castro, Cristina
Date Issued
Apr-2020
Publisher
ELSEVIER SCI LTD
Abstract
The capsular material from Lactobacillus plantarum IMB19, an isolate from fermented vegetables, has been analyzed and our results demonstrate that most of the coat of this bacterium consists of glycerol- and ribitol-type teichoic acids, further decorated with other substituents (a-glucose and alanine), and of a capsular polysaccharide (CPS) with a linear nonasaccharide repeating unit, rich in rhamnose, interconnected to the next via a phosphodiester bridge. Stimulation of immune cells with the total capsular material resulted in the enhancement of immunostimulatory (IFN gamma, TNF-alpha, IL-6 and IL-12) or immuno-regulatory (IL-10) cytokines in an in vitro splenocyte culture system. The capsular polysaccharide, and not the teichoic acids mixture, was responsible for the IFN gamma production. Indeed, a significant increase of IFN gamma along with other inflammatory cytokines, and a dose response in IFN. expression with an EC50 of 3.16 mu M was found for CPS, disclosing that this polysaccharide is a potent immunostimulatory molecule.
URI
http://oasis.postech.ac.kr/handle/2014.oak/103623
ISSN
0144-8617
Article Type
Article
Citation
CARBOHYDRATE POLYMERS, vol. 233, 2020-04
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임신혁IM, SIN HYEOG
Dept of Life Sciences
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