Polysaccharide-Hydrophobic Nanoparticle Hybrid Nanoclusters for Enhanced Performance in Magnetic Resonance/Photoacoustic Imaging
SCIE
SCOPUS
- Title
- Polysaccharide-Hydrophobic Nanoparticle Hybrid Nanoclusters for Enhanced Performance in Magnetic Resonance/Photoacoustic Imaging
- Authors
- Park, J.C.; Kim, D.H.; Park, T.Y.; Cha, H.J.; Seo, J.H.
- Date Issued
- 2019-11
- Publisher
- AMER CHEMICAL SOC
- Abstract
- Polysaccharide-nanoparticle (NP) hybrid nanoclusters have great potential to revitalize diverse bioapplications; however, fabricating polysaccharide-based hybrid nanoclusters composed of high-quality NPs generated in the organic phase remains a challenge. Here, using calcium alginate as a polysaccharide/tetramethylammonium hydroxide (TMAOH) combination, we report a novel approach to the design of alginate-hydrophobic magnetic-plasmonic core-shell (MPCS) NP hybrid nanoclusters (A-MPCS HNCs). Furthermore, we observe the dependence of the formation of A-MPCS HNCs on the TMAOH concentration. The enhanced performance in both magnetic resonance r(2) relaxivity and photoacoustic (PA) signals and the biocompatibility/bioactivity as well as the in vivo performance of A-MPCS HNCs shows them to be a promising magnetic resonance/photoacoustic dual-mode imaging agent. Our strategy could open doors to the use of other precious high quality nanomaterials created in the organic phase via well-established synthetic chemistry in the. design of alginate-hydrophobic nanomaterial hybrid nanoclusters, giving rise to novel and multifarious bioapplications.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/101119
- DOI
- 10.1021/acs.biomac.9b01008
- ISSN
- 1525-7797
- Article Type
- Article
- Citation
- BIOMACROMOLECULES, vol. 20, no. 11, page. 4150 - 4157, 2019-11
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