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Iridium-catalyzed diborylation of benzylic C-H bonds directed by a hydrosilyl group: Synthesis of 1,1-benzyldiboronate esters SCIE SCOPUS

Title
Iridium-catalyzed diborylation of benzylic C-H bonds directed by a hydrosilyl group: Synthesis of 1,1-benzyldiboronate esters
Authors
Cho, SHHartwig, JF
Date Issued
2014-01
Publisher
Royal Society of Chemistry
Abstract
We describe a regioselective diborylation of primary benzylic C-H bonds catalyzed by [Ir(COD)OMe](2) and 4,4'-di-tert-butyl-2,2'-bipyridine (dtbpy). The hydrosilyl group acts as a traceless directing group, providing access to a range of 1,1-benzyldiboronate esters in good yields. Transformations of the 1,1-benzyldiboronate ester products include chemoselective Suzuki-Miyaura cross-couplings and synthesis of tetrasubstituted alkenyl boronate esters.
Keywords
REGIOSPECIFIC FUNCTIONALIZATION; STEREOSELECTIVE-SYNTHESIS; COUPLING REACTIONS; ROOM-TEMPERATURE; BORYLATION; ALKYNES; SP(3)-CARBON; REAGENTS; ALKANES; 1,1-DIBORYLALKANES
URI
https://oasis.postech.ac.kr/handle/2014.oak/10042
DOI
10.1039/C3SC52824C
ISSN
2041-6520
Article Type
Article
Citation
CHEMICAL SCIENCE, vol. 5, no. 2, page. 694 - 698, 2014-01
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