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Bifidobacterium bifidum presents on the cell surface a complex mixture of glucans and galactans with different immunological properties

Title
Bifidobacterium bifidum presents on the cell surface a complex mixture of glucans and galactans with different immunological properties
Authors
Speciale, I.Verma, R.Di Lorenzo, F.Molinaro, A.Im, S.-H.De Castro, C.
Date Issued
Aug-2019
Publisher
ELSEVIER SCI LTD
Abstract
The chemical structure of cell surface polysaccharides isolated from Bifidobacterium bifidum strain PRI1, an important member of the gut microbiota of breast-fed infants, has been elucidated by chemical and NMR spectroscopy analysis. Results demonstrated that the bacterium produces a complex mixture of polysaccharides that could be classified in two main groups: a phospho-glycero-beta-galactofuranan, PG beta G, and a mixture composed of four neutral polysaccharides named as (CSGG), composed of beta-(1 -> 6)-glucan, beta-(1 -> 4) -galactan, beta-galactofuranan and starch. These two fractions exerted different immune responses when assayed on dendritic cells: PG beta G enhanced pro-inflammatory immune responses by increasing interferon-gamma levels while CSGG induced immunosuppressive regulatory T cells and interleukin-10. These findings demonstrate that bacterial polysaccharides have a distinct role depending on their chemical structure in regulation of the host/bacterium interaction. Our findings suggest that polysaccharides may differentially regulate the host immunity depending on the composition of this complex mixture, either enhancing immunity or inducing immune tolerance.
URI
http://oasis.postech.ac.kr/handle/2014.oak/99455
ISSN
0144-8617
Article Type
Article
Citation
CARBOHYDRATE POLYMERS, vol. 218, page. 269 - 278, 2019-08
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