Open Access System for Information Sharing

Login Library

 

Article
Cited 1 time in webofscience Cited 1 time in scopus
Metadata Downloads

Computational Modeling and Clonogenic Assay for Radioenhancement o Gold Nanoparticles Using 3D Live Cell Images

Title
Computational Modeling and Clonogenic Assay for Radioenhancement o Gold Nanoparticles Using 3D Live Cell Images
Authors
Sung, WonmoJeong, YoonKim, HyejinJeong, HoibinGrassberger, ClemensJung, SeongmoonAhn, G-OneKim, Il HanSchuemann, JanLee, KangwonYe, Sung-Joon
Date Issued
Nov-2018
Publisher
Radiation Research Society
Abstract
Radioenhancement of gold nanoparticles (GNPs) has shown great potential for increasing the therapeutic efficiency of radiotherapy. Here we report on a computational model of radiation response, which was developed to predict the survival curves of breast cancer cells incubated with GNPs. The amount of GNP uptake was estimated using inductively coupled plasma-mass spectroscopy, and the three-dimensional (3D) intracellular distribution of GNPs was obtained using optical diffraction tomography. The developed computational model utilized the 3D live cell imaging and recent Monte Carlo techniques to calculate microscopic dose distributions within the cell. Clonogenic assays with and without GNPs were performed to estimate the radioenhancement for 150 kVp X rays in terms of cell survival fractions. Measured cell survival fractions were comparable with the computational model. (C) 2018 by Radiation Research Society
URI
http://oasis.postech.ac.kr/handle/2014.oak/99230
ISSN
0033-7587
Article Type
Article
Citation
Radiation Research, vol. 190, no. 5, page. 558 - 564, 2018-11
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

 AHN, G ONE
Div of Integrative Biosci & Biotech
Read more

Views & Downloads

Browse