Open Access System for Information Sharing

Login Library

 

Article
Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Directed Differentiation of Pluripotent Stem Cells by Transcription Factors

Title
Directed Differentiation of Pluripotent Stem Cells by Transcription Factors
Authors
OH, YUJEONGJANG, JIWON
Date Issued
Mar-2019
Publisher
한국분자세포생물학회
Abstract
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been used as promising tools for regenerative medicine, disease modeling, and drug screening. Traditional and common strategies for pluripotent stem cell (PSC) differentiation toward disease-relevant cell types depend on sequential treatment of signaling molecules identified based on knowledge of developmental biology. However, these strategies suffer from low purity, inefficiency, and time-consuming culture conditions. A growing body of recent research has shown efficient cell fate reprogramming by forced expression of single or multiple transcription factors. Here, we review transcription factor-directed differentiation methods of PSCs toward neural, muscle, liver, and pancreatic endocrine cells. Potential applications and limitations are also discussed in order to establish future directions of this technique for therapeutic purposes.
URI
http://oasis.postech.ac.kr/handle/2014.oak/98556
ISSN
1016-8478
Article Type
Article
Citation
Molecules and Cells, vol. 42, no. 3, page. 200 - 209, 2019-03
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Views & Downloads

Browse