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T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells

Title
T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells
Authors
Kim, Hye-RanMun, YeVinLee, Kyung-SikPark, Yoo-JinPark, Jeong-SuPark, Jin-HwaJeon, Bu-NamKim, Chang-HyunJun, YoungsooHyun, Young-MinKim, MinsooLee, Sang-MyeongPark, Chul-SeungIm, Sin-HyeogJun, Chang-Duk
POSTECH Authors
Im, Sin-Hyeog
Date Issued
Sep-2018
Publisher
NATURE PUBLISHING GROUP
Abstract
Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC) or facilitate adhesion under flow; however, whether they serve essential functions during T cell activation remains unclear. Here we show that antigen-specific T cells deposit membrane particles derived from microvilli onto the surface of cognate antigen-bearing APCs. Microvilli carry T cell receptors (TCR) at all stages of T cell activation and are released as large TCR-enriched, T cell microvilli particles (TMP) in a process of trogocytosis. These microvilli exclusively contain protein arrestin-domain-containing protein 1, which is directly involved in membrane budding and, in combination with vacuolar protein-sorting-associated protein 4, transforms large TMPs into smaller, exosome-sized TMPs. Notably, TMPs from CD4(+) T cells are enriched with LFA-2/CD2 and various cytokines involved in activating dendritic cells. Collectively, these results demonstrate that T cell microvilli constitute "immunological synaptosomes" that carry T cell messages to APCs.
Keywords
CD2 antigen; cell membrane protein; retina S antigen; T lymphocyte receptor; unclassified drug; vacuolar protein sorting associated protein 4; lymphocyte antigen receptor; antigen; cell component; immune system; membrane; protein; animal cell; antigen presenting cell; Article; CD4+ T lymphocyte; cell budding; cell membrane; cell size; cell surface; cell transformation; dendritic cell; exosome; human; human cell; microvillus; mouse; nonhuman; phenomena and functions of biological membrane; protein expression; synaptosome; T lymphocyte; T lymphocyte activation; trogocytosis; animal; antigen presenting cell; HEK293 cell line; Jurkat cell line; membrane microparticle; metabolism; microvillus; physiology; synaptosome; ultrastructure; Animals; Antigen-Presenting Cells; CD4-Positive T-Lymphocytes; Cell-Derived Microparticles; Dendritic Cells; HEK293 Cells; Humans; Jurkat Cells; Mice; Microvilli; Receptors, Antigen, T-Cell; Synaptosomes
URI
http://oasis.postech.ac.kr/handle/2014.oak/94628
DOI
10.1038/s41467-018-06090-8
ISSN
2041-1723
Article Type
Article
Citation
NATURE COMMUNICATIONS, vol. 9, no. 1, 2018-09
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 IM, SIN HYEOG
Div of Integrative Biosci & Biotech
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