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Design and optimization of genetically encoded biosensors for high-throughput screening of chemicals

Title
Design and optimization of genetically encoded biosensors for high-throughput screening of chemicals
Authors
LIM, HYUNGYUJANG, SUNGHOSUNGYEON, JANGSeo, Sang WooJung, Gyoo Yeol
POSTECH Authors
Jung, Gyoo Yeol
Date Issued
Dec-2018
Publisher
CURRENT BIOLOGY LTD
Abstract
Evolutionary engineering of microbes for the production of metabolites requires efficient screening methods to test vast mutant libraries. Genetically encoded biosensors are regarded as promising screening devices owing to their wide range of detectable ligands and great applicability to high-throughput screening and selection. Here, we reviewed the current progress in design and optimization of biosensors for high-throughput screening of chemicals. First, we summarized genetic parts of biosensors and strategies for their discovery and development. Next, we explained the properties of biosensors that are relevant to high-throughput screening. Finally, we described various methods for tuning biosensors to fulfill requirements of an efficient screening.
URI
http://oasis.postech.ac.kr/handle/2014.oak/94481
DOI
10.1016/j.copbio.2018.01.011
ISSN
0958-1669
Article Type
Article
Citation
CURRENT OPINION IN BIOTECHNOLOGY, 2018-12
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 JUNG, GYOO YEOL
Dept. of Chemical Enginrg
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