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Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C-elegans

Title
Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C-elegans
Authors
Heehwa G. SonKeunhee SeoMihwa SeoSANGSOON, PARKSeokjin HamAN, SEON WOOEun-Seok ChoiLEE, YUJINHaeshim BaekEunju KimYoungjae RyuChang Man HaAo-Lin HsuROH, TAE YOUNGJANG, SUNG KEYLEE, SEUNG JAE
POSTECH Authors
ROH, TAE YOUNGJANG, SUNG KEYLEE, SEUNG JAE
Date Issued
1-Dec-2018
Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Abstract
Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS.
Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS.
Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS.
Keywords
CAENORHABDITIS-ELEGANS; LIFE-SPAN; TRANSCRIPTION FACTORS; INTEGRATIVE ANALYSIS; EXPRESSION; DAF-16; PROTEIN; CHAPERONE; GENES; HSP90
URI
http://oasis.postech.ac.kr/handle/2014.oak/94480
DOI
10.1101/gad.317362.118
ISSN
0890-9369
Article Type
Article
Citation
GENES & DEVELOPMENT, vol. 32, no. 23-24, page. 1562 - 1575, 2018-12-01
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 ROH, TAE YOUNG
Div of Integrative Biosci & Biotech
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