Open Access System for Information Sharing

Login Library

 

Article
Cited 66 time in webofscience Cited 78 time in scopus
Metadata Downloads

Amino-acid- and peptide-directed synthesis of chiral plasmonic gold nanoparticles

Title
Amino-acid- and peptide-directed synthesis of chiral plasmonic gold nanoparticles
Authors
Lee, Hye-EunAhn, Hyo-YongMun, JunghoLee, Yoon YoungKim, MinkyungCho, Nam HeonChang, KiseokKim, Wook SungRho, JunsukNam, Ki Tae
POSTECH Authors
Kim, Wook SungRho, Junsuk
Date Issued
Apr-2018
Publisher
NATURE PUBLISHING GROUP
Abstract
Understanding chirality, or handedness, in molecules is important because of the enantioselectivity that is observed in many biochemical reactions(1), and because of the recent development of chiral metamaterials with exceptional light-manipulating capabilities, such as polarization control(2-4), a negative refractive index(5) and chiral sensing(6). Chiral nanostructures have been produced using nanofabrication techniques such as lithography(7) and molecular self-assembly(8-11), but large-scale and simple fabrication methods for three-dimensional chiral structures remain a challenge. In this regard, chirality transfer represents a simpler and more efficient method for controlling chiral morphology(12-18). Although a few studies(18,19) have described the transfer of molecular chirality into micrometre-sized helical ceramic crystals, this technique has yet to be implemented for metal nanoparticles with sizes of hundreds of nanometres. Here we develop a strategy for synthesizing chiral gold nanoparticles that involves using amino acids and peptides to control the optical activity, handedness and chiral plasmonic resonance of the nanoparticles. The key requirement for achieving such chiral structures is the formation of high-Miller-index surfaces ({hkl}, h not equal k not equal l not equal 0) that are intrinsically chiral, owing to the presence of 'kink' sites(20-22) in the nanoparticles during growth. The presence of chiral components at the inorganic surface of the nanoparticles and in the amino acids and peptides results in enantioselective interactions at the interface between these elements; these interactions lead to asymmetric evolution of the nanoparticles and the formation of helicoid morphologies that consist of highly twisted chiral elements. The gold nanoparticles that we grow display strong chiral plasmonic optical activity (a dissymmetry factor of 0.2), even when dispersed randomly in solution; this observation is supported by theoretical calculations and direct visualizations of macroscopic colour transformations. We anticipate that our strategy will aid in the rational design and fabrication of three-dimensional chiral nanostructures for use in plasmonic metamaterial applications.
Understanding chirality, or handedness, in molecules is important because of the enantioselectivity that is observed in many biochemical reactions(1), and because of the recent development of chiral metamaterials with exceptional light-manipulating capabilities, such as polarization control(2-4), a negative refractive index(5) and chiral sensing(6). Chiral nanostructures have been produced using nanofabrication techniques such as lithography(7) and molecular self-assembly(8-11), but large-scale and simple fabrication methods for three-dimensional chiral structures remain a challenge. In this regard, chirality transfer represents a simpler and more efficient method for controlling chiral morphology(12-18). Although a few studies(18,19) have described the transfer of molecular chirality into micrometre-sized helical ceramic crystals, this technique has yet to be implemented for metal nanoparticles with sizes of hundreds of nanometres. Here we develop a strategy for synthesizing chiral gold nanoparticles that involves using amino acids and peptides to control the optical activity, handedness and chiral plasmonic resonance of the nanoparticles. The key requirement for achieving such chiral structures is the formation of high-Miller-index surfaces ({hkl}, h not equal k not equal l not equal 0) that are intrinsically chiral, owing to the presence of 'kink' sites(20-22) in the nanoparticles during growth. The presence of chiral components at the inorganic surface of the nanoparticles and in the amino acids and peptides results in enantioselective interactions at the interface between these elements; these interactions lead to asymmetric evolution of the nanoparticles and the formation of helicoid morphologies that consist of highly twisted chiral elements. The gold nanoparticles that we grow display strong chiral plasmonic optical activity (a dissymmetry factor of 0.2), even when dispersed randomly in solution; this observation is supported by theoretical calculations and direct visualizations of macroscopic colour transformations. We anticipate that our strategy will aid in the rational design and fabrication of three-dimensional chiral nanostructures for use in plasmonic metamaterial applications.
Keywords
amino acid derivative; gold nanoparticle; peptide derivative; amino acid; cysteine; gold; metal nanoparticle; peptide; amino acid; chemical reaction; gold; handedness; nanoparticle; peptide; refractive index; three-dimensional modeling; Article; chirality; enantioselectivity; hardness; light; nanofabrication; polarization; priority journal; synthesis; chemistry; circular dichroism; optical rotation; photometry; procedures; radiation response; stereoisomerism; synthesis; Helicoidea; Amino Acids; Chemistry Techniques, Synthetic; Circular Dichroism; Cysteine; Gold; Light; Metal Nanoparticles; Optical Rotation; Peptides; Photometry; Stereoisomerism
URI
http://oasis.postech.ac.kr/handle/2014.oak/94301
DOI
10.1038/s41586-018-0034-1
ISSN
0028-0836
Article Type
Article
Citation
NATURE, vol. 556, no. 7701, page. 360 - 365, 2018-04
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

 KIM, WOOKSUNG
Dept of Electrical Enginrg
Read more

Views & Downloads

Browse