Selective cancer targeting by non-thermal air plasma with epidermal growth factor (EGF)-conjugated goldnanoparticle (GNP)
- Selective cancer targeting by non-thermal air plasma with epidermal growth factor (EGF)-conjugated goldnanoparticle (GNP)
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- Apoptosis, a programmed cell death, is a very important pathway that balances systemic homeostasis of multi-cellular organisms. Notably, apoptosis is the most frequently adopted method to terminate cancer cells. Cellular apoptosis by non-thermal air plasma irradiation was previously reported but showed no target specificity. Here, we describe a novel method of non-thermal air plasma-mediated cancer therapeutics with enhanced target specificity by combining treatment of EGF - conjugated GNP. We adopted two linkers, MUA and MHDA, to conjugate EGF with GNP. The combinatorial treatment of EGF - conjugated GNP complex and plasma showed receptor-mediated endocytosis, followed by release of cytochrome c which indicates cell death. These results suggest that EGF - conjugated GNP functions as an important adjuvant which gives target specificity in applications of conventional plasma medicine.
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