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Microfluidic Fabrication of Microparticles for Biomedical Applications

Title
Microfluidic Fabrication of Microparticles for Biomedical Applications
Authors
Li, WenZhang, LiyuanGe, XuehuiXu, BiyiZhang, WeixiaQu, LiangliangChoi, Chang-HyungXu, JianhongZhang, AfangLEE, HYOMINWeitz, David A.
POSTECH Authors
LEE, HYOMIN
Date Issued
Jul-2018
Publisher
ROYAL SOC CHEMISTRY
Abstract
Droplet microfluidics offers exquisite control over the flows of multiple fluids in microscale, enabling fabrication of advanced microparticles with precisely tunable structures and compositions in a high throughput manner. The combination of these remarkable features with proper materials and fabrication methods has enabled high efficiency, direct encapsulation of actives in microparticles whose features and functionalities can be well controlled. These microparticles have great potential in a wide range of bio-related applications including drug delivery, cell-laden matrices, biosensors and even as artificial cells. In this review, we briefly summarize the materials, fabrication methods, and microparticle structures produced with droplet microfluidics. We also provide a comprehensive overview of their recent uses in biomedical applications. Finally, we discuss the existing challenges and perspectives to promote the future development of these engineered microparticles.
Droplet microfluidics offers exquisite control over the flows of multiple fluids in microscale, enabling fabrication of advanced microparticles with precisely tunable structures and compositions in a high throughput manner. The combination of these remarkable features with proper materials and fabrication methods has enabled high efficiency, direct encapsulation of actives in microparticles whose features and functionalities can be well controlled. These microparticles have great potential in a wide range of bio-related applications including drug delivery, cell-laden matrices, biosensors and even as artificial cells. In this review, we briefly summarize the materials, fabrication methods, and microparticle structures produced with droplet microfluidics. We also provide a comprehensive overview of their recent uses in biomedical applications. Finally, we discuss the existing challenges and perspectives to promote the future development of these engineered microparticles.
URI
http://oasis.postech.ac.kr/handle/2014.oak/92158
DOI
10.1039/C7CS00263G
ISSN
0306-0012
Article Type
Article
Citation
CHEMICAL SOCIETY REVIEWS, vol. 47, no. 15, page. 5646 - 5683, 2018-07
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 LEE, HYOMIN
Dept. of Chemical Enginrg
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